Here, we show that the kinase ATR localizes to XY chromatin at the onset of MSCI and that this localization is disrupted in mice with a mutant form of the tumor suppressor protein BRCA1. In the mutant pachytene
Full Namebreast cancer 1, early onset Calculated Molecular Weight208 kDa Observed Molecular Weight230-260 kDa GenBank Accession NumberNM_007294 Gene SymbolBRCA1 Gene ID (NCBI)672 ConjugateUnconjugated FormLiquid Purification MethodAntigen affinity purification ...
and signal transducers to form a large multi-subunit protein complex known as the BRCA1-associated genome surveillance complex (BASC). This gene product associates with RNA polymerase II, and through the C-terminal domain, also interacts with histone deacetylase complexes. This protein thus plays a...
BRCA1 DNA修复相关 基因检测报告英文版基因简介 This gene encodes a nuclear phosphoprotein that plays a role in maintaining genomic stability, and it also acts as a tumor suppressor. The encoded protein combines with other tumor suppressors, DNA damage sensors, and signal transducers to form a large...
and signal transducers to form a large multi-subunit protein complex known as the BRCA1-associated genome surveillance complex (BASC). This gene product associates with RNA polymerase II, and through the C-terminal domain, also interacts with histone deacetylase complexes. This protein thus plays a...
The encoded protein combines with other tumor suppressors, DNA damage sensors, and signal transducers to form a large multi-subunit protein complex known as the BRCA1-associated genome surveillance complex (BASC). This gene product associates with RNA polymerase II, and through the C-terminal ...
Using this antibody for immunostaining, we found that PTIP is a pan-nuclear protein in unda- maged HeLa cells and form foci after exposure to γ- irradiation. In addition, the foci formation of PTIP were 53BP1 and ATM dependent (Supplementary Figure S1b), as previously reported [9]. ...
Our data show that the BRCA1-DNA complexes are stabilized, mainly through ‘head-on’ interaction between BRCA1 and the DNA double-strand ends. ‘Side-on’ binding to the DNA major grove was insufficient to form stable complexes. When bound to the nucleic acid, the IDR maintained high ...
GeneTex验证 BRCA1抗体 [6B4] - ChIP grade (GTX70115).3篇文献引用。可与 Human 样本反应。可应用于 WB, ICC/IF, IHC-P, IP, ChIP assay, IHC。
The encoded protein combines with other tumor suppressors, DNA damage sensors, and signal transducers to form a large multi-subunit protein complex known as the BRCA1-associated genome surveillance complex (BASC). This gene product associates with RNA polymerase II, and through the C-terminal ...