BRCA1, BRCA2 and their possible function * in DNA damage response. Br J Cancer 1999, 81:1099-1102. This review summarises the evidence that BRCA1 and BRCA2 are involved in the DNA damage response.Kote-Jarai, Z., and Eeles, R. A. BRCA1, BRCA2 and their possible function in DNA ...
To improve methods for predicting the impact of missense variants of uncertain significance (VUS) in BRCA1 and BRCA2 on protein function. Functional data for 248 BRCA1 and 207 BRCA2 variants from assays with established high sensitivity and specificity f
The proteins encoded by the two major breast cancer susceptibility genes,BRCA1andBRCA2, work in a common pathway of genome protection. However, the two proteins work at different stages in the DNA damage response (DDR) and in DNA repair. BRCA1 is a pleiotropic DDR protein that functions in...
Thus, there is evidence for BRCA1 involvement in both G1 and G2 checkpoints. View article Remodelling the function of BRCA1 Jan de Boer, in Trends in Cell Biology, 2000 Can we conclude that BRCA1 is the pilot, guiding the chromatin-remodelling SWI/SNF complex to the site of DNA damage...
The BRCA1 protein, a hereditary breast and ovarian cancer-causing gene product, is known as a multifunctional protein that performs various functions in ce
LOH is associated with better survival rates and therapeutic implications, as the absence of BRCA1/2 function due to LOH renders tumors sensitive to PARPi and mainly to platins [51], as LOH is necessary for tumor sensitivity to platins and LOH absence is connected with a worse prognosis und...
The BRCA1 and BRCA2 proteins are important in maintaining genomic stability by promoting efficient and precise repair of double-strand breaks. The main role of BRCA2 appears to involve regulating the function of RAD51 in the repair by homologous recombination. BRCA1 has a broader role upstream ...
Thousands of BRCA1 and BRCA2 mutations with unambiguously severe effects on cancer risk have been identified, nearly all of which truncate or delete their host gene.3 In addition, a dozen or so amino acid substitutions have been proven experimentally to lead to loss of function of either BRCA...
These observations suggest that BN induced carcinogenesis is associated with genomic instability and may involve loss-of-function of genes involved in the maintenance of genomic integrity. In fact, global gene expression profiling in human gingival fibroblasts (HGF) exposed to arecoline, the major ...
These proteins function predominantly in the nucleus to regulate cell cycle progression, DNA repair/recombination and gene transcription, and their export to the cytoplasm has been linked to apoptosis. Germ-line mutations in the BRCA1/BRCA2 and BARD1 genes predispose to risk of breast/ovarian ...