(2000). BRCA1 is associated with a human SWI/SNF-related complex: linking chromatin remodeling to breast cancer. Cell 102, 257-265.Bochar, D.A., Wang, L., Beniya, H., Kinev, A., Xue, Y., Lane, W.S., Wang, W., Kashanchi, F. and Shiekhattar, R. (2000) BRCA1 is ...
Molecular Characterization and Cancer Risk Associated with BRCA1 and BRCA2 Splice Site Variants Identified in Multiple‐Case Breast Cancer FamiliesNo is available for this article.doi:10.1002/humu.22526A. A. Tesoriero... AA Tesoriero,EM Wong,MA Jenkins,... - 《Human Mutation》 被引量: 0发表...
Activation of de novo fatty acid synthesis is a characteristic feature of cancer cells. We have recently described an interaction between acetyl-CoA carbox... Chajes,V. - 《Cancer Research》 被引量: 628发表: 2006年 Novel signaling molecules implicated in tumor-associated fatty acid synthase-depend...
In 1990, a breast cancer susceptibility gene, designated BRCA1, was localized to chromosome 17q. Mutations within this gene are believed to account for approximately 45% of families with high incidence of breast cancer and at least 80% of families with increased incidence of both early-onset br...
Uterine serous carcinoma (USC) is a rare and deadly form of endometrial cancer. It is unclear whether BRCA1 pathogenic variants (PV) are associated with an increased risk of USC. Because patients with triple-negative br...
BRCA2in prostate cancer patients in Israel. Br J Cancer. 2000;83:463–6. Google Scholar mutation related prostate cancer among Ashkenazi Israelis is not associated with distinctive histopathology. J Med Genet. 2003;40:787–92. CASPubMedPubMed CentralGoogle Scholar ...
BRCA1 (breast and ovarian cancer susceptibility protein 1) is a nuclear phosphoprotein that plays a role in maintaining genomic stability and acts as a tumor suppressor in combination with other tumor suppressors, DNA damage sensors, and signal transducers to form a large multi-subunit protein compl...
A very important aspect of this etiology is genomic instability, which is associated with the loss of activity of the breast cancer-predisposing genes BRCA1 and BRCA2. In sporadic breast cancer, however, there is evidence for the involvement of a different pathway of DNA repair, nucleotide ...
Cancer Res 2000; 60: 5329–5333. CAS Google Scholar Rice JC, Ozcelik H, Maxeiner P, Andrulis I, Futscher BW . Methylation of the BRCA1 promoter is associated with decreased BRCA1 mRNA levels in clinical breast cancer specimens. Carcinogenesis 2000; 21: 1761–1765. CAS Google Scholar ...
Cancer stem cells contribute to cisplatin resistance in Brca1/p53-mediated mouse mammary tumors. The majority of BRCA1-associated breast cancers are basal cell–like, which is associated with a poor outcome. Using a spontaneous mouse mammary tumor mode... N Shafee,CR Smith,S Wei,... - 《...