Being Young, Female, and BRCA Positive A qualitative study finds that young women with a BRCA gene mutation have concerns about marriage and childbearing.In 2006-2007,1 conducted a grounded theory study of young women, ages 18 to 39, who had been tested for a BRCA mutation, the presence ...
PARP inhibitors function by blocking the repair of single-strand breaks in DNA, leading to the accumulation of double-strand breaks that are lethal to cells with defective HRR mechanisms, such as BRCA-mutant cells. This mechanism of action, known as synthetic lethality, has been a significant br...
Eligible patients were female or male adults with: primary operable, histologically confirmed, HER2-negative, localized BC; deleterious/suspected deleterious BRCA1/2 mutations (germline, may include somatic); primary tumor size ≥1 cm; and Eastern Cooperative Oncology Group performance status 0–1....
2007 and December 31, 2014, a total of 292 female TNBC patients withBRCA1/2 mutation were enrolled. We performed logistic regression analysis in patients withoutBRCA1/2 germline mutation (n=261) andBRCA1/2 germline mutation
(MN)-positive cells prepared from DLD1.BRCA2wild typeand DLD1.BRCA2‒/‒cells exposed to DMSO or ART558 for 48 h.n = 3 independent experiments. Two-tailed Student’st-test was used to calculatepvalue.kDose–response ART558 survival curves inBRCA2mutant CAPAN1 parental or ...
BRCA mutation-positive status was determined by NLP-related data fields. While the data source indicated the presence of BRCA muta- tions, it did not provide information on whether the mutations were germline or somatic in origin. The Optum EHR database was selected primarily due to the...
Epithelial ovarian cancer is the most lethal malignancy of the female genital tract. With respect to treatment and prognosis, primary carcinomas of the ovaries, fallopian tubes and peritoneum are considered one disease entity often referred to as ‘ovarian carcinoma’. Women with germline mutations i...
While this recommendation applies to women, the net benefit estimates are driven by biological sex (ie, male/female) rather than gender identity. Persons should consider their sex at birth to determine which recommendation best applies to them. Assessment of Risk Mutations in the BRCA1/2 genes ...
Moreover, 998 (64.2%) were luminal, 247 (15.9%) were triple-negative breast cancer, and 126 (8.1%) were human epidermal growth factor receptor 2–positive (HER2+) cancer. A total of 26.2% were diagnosed with bilateral breast cancer. Among 146 patients with gynecologic tumors, the mean ...
positive for p63 or TCF7 or both proteins.p-value indicates the significant association of the p63/TCF7 positive/negative status of CD10+myoepithelial cells with condition (Control,BRCA1, orBRCA2), as assessed by Pearson’s chi-squared test among averages of estimated cell counts across ...