Deletion of this positive regulatory region resulted in a significant loss of promoter activity. Utilizing DNA binding assays, proteins with specific affinities for the positive regulatory region were detected. Disruption of the DNA-protein complexes could affect normal BRCA1 transcription and may ...
and though she contacted the company she trusts most,Myriad Oncology, personally and put a rush on it, it wasn’t until two weeks later I found out I had tested positive for the BRCA1 gene mutation.
虽然BRCA1是由于其在癌症生物学中的作用及其基因组活性而被发现的,但越来越多的证据表明,BRCA1表现出一系列不属于经典癌症相关作用类型的作用。在其他生理活性中,BRCA1显示诱导乳腺癌细胞的代谢调整,是控制脂肪生成途径的重要步骤,与IGF1、雌激素和雄激素的相互作用并在能量代谢中...
it is unclear how the mutation in a single allele of BRCA1 contributes to ovarian carcinogenesis. Thus, establishment of an immortalized cell line carryingBRCA1 mutation may provide a useful model to study the tumorige...
The methylation of BRCA1, RASSF1Aand GSTP1 was found in 58.23 %, 74.68 % and 59.49 % of tumor tissues and 51.90 %, 63.29 % and 35.44 % ofcorresponding adjacent tissues, respectively. When each gene was assessed individually, only the methylation ofGSTP1 was significantly associated with ...
Germline mutations in the BRCA1 gene have been associated with familial breast/ovarian cancer. Furthermore, women diagnosed of early-onset breast cancer have a higher probability of being carriers of BRCA1 mutations. Our aim was to know prevalence of BRCA1 mutations in women with breast cancer ...
On cytology/cell blocks, benign mesothelial cells were invariably positive for BAP1, whereas 64% of mesotheliomas showed loss of protein; all 6 cases showing BAP1 negativity were associated with histological diagnosis of BAP1-negative mesothelioma. BAP1 stain also showed utility in the differential...
探讨人表皮生长因子受体2（human epidermal growth factor receptor 2，HER2）和乳腺癌易感基因1（breast cancer susceptibility gene 1，BRCA1）在乳腺癌患者中的表达，并研究两者的表达与放疗敏感性的相关性，以期为临床治疗提供依据。方法：回顾并分析郑州大学附属肿瘤医院收治的156例乳腺癌患者的癌变组织和相邻正常乳腺...
Suggested positive control: U2OS and MCF-7 whole cell lysates. 靶标信息 BRCA1 (breast and ovarian cancer susceptibility protein 1) is a nuclear phosphoprotein that plays a role in maintaining genomic stability and acts as a tumor suppressor in combination with other tumor suppressors, DNA damage ...
The most common form of genetic variation in patients with breast cancer was 5382insC mutation in BRCA1 gene, which was 14.59% of the total number of examined patients and 90% of the total number of positive results. BRCA1 and ... LM Saрtarova,EN Cogina,LM Khasanshina,... - 《Kaz...