Chemotherapy Drugs for Brain TumorsUK, Cancer Research
A major impediment to treating the deadly brain cancer glioblastoma has been that the most potent chemotherapy can't permeate the blood-brain barrier to reach the aggressive brain tumor. But now Northwestern Medicine scientists report results of the first in-human clinical trial in which they used ...
Radiation also can be given by putting radioactive material into the tumor itself.Chemotherapy uses drugs to stop the growth of cancer cells. It can be taken by mouth, injected into a vein or muscle, or placed directly into a body part. In general, chemotherapy tends to be less effective ...
brain tumorchemotherapyinterstitialintra-arterialmetastaticmolecularMetastatic brain tumors are the most common complication of systemic cancer and affect 20-40% of all adult cancer patients. Whole-brain radiotherapy and surgical resection of accessible, solitary lesions have been the mainstay of treatment....
and have been used in GBM patients to inhibit tumor growth and resistance to drugs. If autophagy is found to have harmful effects, promoting it could hinder the development of brain tumors. mTOR inhibitors and natural compounds have been utilized to trigger autophagy. Rapamycin and everolimus, whi...
One of the biggest challenges in treating glioblastoma, a fatal brain cancer, is that the most effective chemotherapy drugs cannot penetrate the blood-brain barrier to reach the fast-growing brain tumor. Northwestern Medicine researchers have recently reported the results of the first human clinical ...
Salvage chemotherapy for recurrent primary brain tumors in children Sixty consecutive evaluable children with recurrent primary tumors of the central nervous system were treated with a regimen of vincristine, nitrogen mustard, procarbazine, and prednisone over a 12-year period. Tumor types included medul...
the results of preradiation chemotherapy in very young children have been disappointing.[3] It is likely that medulloblastoma in a child under age 3 years is a much more malignant tumor than the same tumor in an older child. The results of chemotherapy in this select population, then, may ...
Glioblastomas are aggressive brain tumors with a median survival time of less than 22 months despite standard therapy including surgery, irradiation, and chemotherapy. It has become clear in recent years that not all cells within the brain tumor have an equal potential to divide and drive tumor ...
Resistance to chemotherapy in brain tumors is complex and may involve multiple mechanisms. For commonly used drugs, such as nitrosoureas and platinum compounds, major mechanisms may involve increaded DNA repair or removal of the drug-DNA adducts. For water soluble nitrosoureas and also for platinum...