Reference: “A single-cell multi-omic atlas spanning the adult rhesus macaque brain” by Kenneth L. Chiou, Xingfan Huang, Martin O. Bohlen, Sébastien Tremblay, Alex R. DeCasien, Diana R. O’Day, Cailyn H. Spurrell, Aishwarya A. Gogate, Trisha M. Zintel, Cayo Biobank Resea...
In this resource, we present the Brain Cell Atlas, a unified single-cell atlas of the human brain assembled from 70 studies, with 11.3M cells or nuclei that covered nearly all major regions of the brain in health and diseases as well as 103 studies of mouse data of 15M cells. We demon...
Single-cell 'atlas' reveals origin of an aggressive brain tumor单细胞 "图谱 "揭示了一种侵略性脑瘤的起源 souyou 科研新闻,不定期更新!对小鼠的研究已经使百科全书充满了突破性的医学发现。但是当涉及到脑癌时,这种小啮齿动物长期以来一直表现出基本的局限性。 其中包括:人类小脑的表面积是小鼠的750倍,所有...
Schematic workflow of the three technologies for investigating the multimodal nature of the primate brain atlas.AAbridged general view of the organization pattern of the target area.B–ESchematic of a single-cell/single-nucleus RNA-seq experiment.BPreparation of single-cell/single-nucleus suspension.C...
While single-cell technologies have greatly advanced our comprehension of human brain cell types and functions, studies including large numbers of donors and multiple brain regions are needed to extend our understanding of brain cell heterogeneity. Integrating atlas-level single-cell data presents a ...
Here we created a comprehensive molecular atlas of the human brain vasculature using single-cell RNA sequencing (scRNA-seq) analysis in the developing, adult/control and diseased human brain (Fig. 1a, Extended Data Fig. 1 and Supplementary Methods). We identified extensive heterogeneity among ECs ...
The human cortex comprises diverse cell types that emerge from an initially uniform neuroepithelium that gives rise to radial glia, the neural stem cells of the cortex. To characterize the earliest stages of human brain development, we performed single-cell RNA-sequencing across regions of the deve...
A comparative atlas of single-cell chromatin accessibility in the human brain 发表期刊和时间:Science,13 October 2023 Lab:Bing Ren, 实验室正在研究正常和癌症细胞的基因调节机制,与路德维希研究所和加州大学合作密切。 摘要:探索了三名成年人42个大脑区域110万个细胞的开放染色质景观。整合这些数据揭示了107种...
Now a multinational team of scientists led by experts at Cincinnati Children's has developed an "atlas" of human fetal brain development so detailed that it details growth steps all the way down to changes occurring at the single-cell level. Details were published Nov. 30 inNature. ...
While the roles of parenchymal microglia in brain homeostasis and disease are fairly clear, other brain-resident myeloid cells remain less well understood. By dissecting border regions and combining single-cell RNA-sequencing with high-dimensional cytome