Reference: “A single-cell multi-omic atlas spanning the adult rhesus macaque brain” by Kenneth L. Chiou, Xingfan Huang, Martin O. Bohlen, Sébastien Tremblay, Alex R. DeCasien, Diana R. O’Day, Cailyn H. Spurrell, Aishwarya A. Gogate, Trisha M. Zintel, Cayo Biobank Rese...
Here we created a comprehensive molecular atlas of the human brain vasculature using single-cell RNA sequencing (scRNA-seq) analysis in the developing, adult/control and diseased human brain (Fig. 1a, Extended Data Fig. 1 and Supplementary Methods). We identified extensive heterogeneity among ECs ...
While single-cell technologies have greatly advanced our comprehension of human brain cell types and functions, studies including large numbers of donors and multiple brain regions are needed to extend our understanding of brain cell heterogeneity. Integrating atlas-level single-cell data presents a chan...
Researchers from the Salk Institute, in a global collaboration, have produced a detailed atlas of human brain cells by analyzing over half a million cells. The study, part of the NIH’s BRAIN Initiative, marks a pivotal shift in understanding brain cell diversity and function. The new rese...
Cell–cell interaction analyses predict substantial endothelial-to-perivascular cell ligand–receptor cross-talk, including immune-related and angiogenic pathways, thereby revealing a central role for the endothelium within brain neurovascular unit signalling networks. Our single-cell brain atlas provides ...
Overview of the Brain Cell Atlas The resource, which is also provided as an interactive web portal, includes 11.3M human cells from 14 main regions and 30 subregions of the brain (Supplementary Fig.1), while the mouse data include 15M cells. Single-cell RNA sequencing and single-nucleus RNA...
The human cortex comprises diverse cell types that emerge from an initially uniform neuroepithelium that gives rise to radial glia, the neural stem cells of the cortex. To characterize the earliest stages of human brain development, we performed single-cell RNA-sequencing across regions of the deve...
The development of single-cell and spatial transcriptomics methods was instrumental in the conception of the Human Cell Atlas initiative, which aims to generate an integrated map of all cells across the human body. These technology advances are bringing increasing depth and resolution to maps of huma...
Single-cell atlas of the human brain vasculature across development, adulthood and disease Article Open access 10 July 2024 A human brain vascular atlas reveals diverse mediators of Alzheimer’s risk Article 14 February 2022 Profiling human brain vascular cells using single-cell transcriptomics an...
Single-cell-atlas-of-the-human-brain-vasculature-across-development-adulthood-and-disease Publicaiton link: https://www.nature.com/articles/s41586-024-07493-y Abstract A broad range of brain pathologies critically relies on the vasculature, and cerebrovascular disease is a leading caus...