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The Brain Is Key to Controlling CholesterolRead the full-text online article and more details about "The Brain Is Key to Controlling Cholesterol" - Daily Mail (London), June 7, 2010Daily Mail (London)
On the other hand, higher adherence to patterns based on B vitamins, retinol, proteins, fats or to inflammation-related dietary pattern (characterized by low intakes of calcium, vitamin D, vitamins E, A, B, folate, ω-3 PUFAs, and high intake of cholesterol), were associated with smaller...
The brain is responsible for regulating the functions of the body, from the unconscious (controlling blood pressure,heartrate, and respiratory rate) to the conscious acts likewalkingand talking. Add the intellectual processes of thought, and the brain is a busy part of the human body. The brain...
Of the main organs of the body, the brain is particularly rich inlipidsand an important aspect of lipid metabolism is the synthesis of lipid components. The brain synthesizes cholesterol,glycerophospholipidsandsphingolipids. This latter group is particularly important in the brain andnervous systemin ...
Low-density lipoprotein receptor-related protein (LRP) as a transmembrane glycoprotein can mediate the uptake of cholesterol-rich low-density lipoprotein, including cholesterol, tocopherol, and Apos.180The family of LRP has a lot of members, such as LRP-1, low-density lipoprotein (LDL) receptor-...
The brain relies exclusively on synthesis from acetate to fulfill its cholesterol requirement. Turnover of cholesterol within neurons is accomplished by the enzyme cholesterol 24-hydroxylase, a cytochrome P450 that converts cholesterol to the more hydrophilic 24()-hydroxycholesterol. This product diffuses...
which included 83 AD cases and 88 control samples with ages greater than 65 years10. To this end, we computed the methylation risk scores (MRS)72, which were shown to have excellent discrimination of smoking status, and moderate discrimination of obesity, alcohol consumption, HDL cholesterol73,...
On a global scale, there is an increasing tendency for a more aggressive treatment of hypercholesterolemia. Minor effects of statins on brain cholesterol metabolism have been reported in some in vivo animal studies, and it seems that this is due to a local effect of the drug. We treated male...
The gray bars on the right side represent the number of detected lipids in each lipid class (Supplementary Data 2). The brain regions on the right side are colored according to the relative abundance levels of cholesterol. Brain images were adapted from ref. 1. b Heatmaps representing the ...