The brain is responsible for regulating the functions of the body, from the unconscious (controlling blood pressure,heartrate, and respiratory rate) to the conscious acts likewalkingand talking. Add the intellectual processes of thought, and the brain is a busy part of the human body. The brain...
Alzheimer’s disease (AD) is the most common cause of dementia and affects about 11% of people 65 years and older in the US1. With the rising elderly population, AD has become a major public health concern. In addition to genetics, it has been increasingly appreciated that epigenetic marks...
Cholesterol metabolism is believed to play a role in the development of Alzheimer's disease (AD). Oxysterol metabolites of cholesterol, 24S-hydroxycholesterol (24-OHC, a brain-derived oxysterol) and 27-hydroxycholesterol (27-OHC, a peripherally derived oxysterol) cross the blood brain barrier and ...
f, Raw and reconstructed mass spectra zoomed into the cholesterol range (left columns) and corresponding ion images showing tissue localization of cholesterol (right columns). Full size image Furthermore, we examined the model performance for reconstructing SCMS data. Specifically, we trained a model...
(APOE2,APOE3, andAPOE4), and has recently been proposed to impair myelinationviacholesterol dysregulation in oligodendrocytes [106,107]. Interestingly, APOE4 organoids exhibit more severe synaptic loss and neurodegeneration phenotypes [108]. Cerebral organoids increase Aβ and p-Tau by inducing ...
Cholesterol for synthesis of myelin is made locally, not imported into brain. We examined whether cholesterol needed for myelin formation is locally synthesized or whether it comes from the circulation. The experimental design was to... H Jurevics,P Morell - 《Journal of Neurochemistry》 被引量:...
Crucially, it was found that approximately ¾ of the extracellular β-amyloid is directly cleared out of the brain by direct vascular transport across the BBB, mostly via the low-density cholesterol receptor-related protein-1 (LRP1), a process believed to be dependent on the apolipoprotein E ...
Cholesterol is a critical brain nutrient essential for the function of neurons, and it plays a fundamental role as a building block of the cell membrane. It acts as an antioxidant and a precursor to important brain-supporting elements like vitamin D, as well as the steroid-related hormones (...
Obesity is linked to cognitive decline and metabolic dysregulation in the brain, yet the role of sex is relatively unexplored. We sought to explore the effects of obesity and sex on the brain metabolome. In male and female ob/ob and wild-type mice, we as
Smith–Lemli–Opitz syndrome is an autosomal recessive disorder caused by mutations in the DHCR7 gene that results in an inborn error of cholesterol synthesis. Features of this syndrome (growth failure, intellectual disability, behavioral problems, autism, and syndactyly of the second and third toes...