Brain metastasisPrimary sitePrimary cancerBreast cancerLung cancerCentral nervous systemCNSWhile the majority of brain metastases arise from lung cancer, breast cancer, or melanoma, new treatments and improved prognoses have altered the profile of primary cancers that metastasize to the brain. We sought...
Therefore, it would be of high interest to understand the nature of breast cancer tumor cells that outgrow in the brain in an effort to prevent this process. Signaling pathways involved in breast cancer brain metastasis Among the different pathways associated with breast can- cer BM formation, ...
Metastatic brain tumors (also termed secondary brain tumors) are made of cancerous cells that spread through the bloodstream from a tumor located elsewhere in the body. The most common cancers that spread to the brain are those arising from cancers that originate in the lung,breast, and kidney ...
A subsequent study randomized 63 patients with systemic cancer and a single brain metastasis to surgical resection plus WBRT vs. WBRT alone. The combined modality led to longer overall survival and longer functionally independent survival compared with WBRT alone, particularly in patients with stable ex...
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The mechanisms of brain metastasis in renal cell cancer (RCC) patients are poorly understood. Chemokine and chemokine receptor expression may contribute to the predilection of RCC for brain metastasis by recruitment of monocytes/macrophages and by control or induction of vascular permeability of the blo...
doi:10.1038/nrc2678Sarah SetonRogersNature Reviews Cancerbreast cancer metastasis to the brain. Nature 459, 1005-1009. Broxterman, H.J., Gotink, K.J., and Verheul, H.M. (2009). Understanding the causes of
Long-term survival in a patient with brain metastases preceding the diagnosis of endometrial cancer 鉁Only five patients found to have brain metastasis preceding the diagnosis of endometrial cancer have been reported in the literature, and none of these ... E Petru,S Lax,S Kurschel,... - 《...
brain metastasisCNS involvementHER2‐positive breast cancerT‐DM1trastuzumabtucatinibBackground Brain metastases (BrM) incidence is 25% to 50% in women with advanced human epidermal growth factor receptor 2 (HER2)﹑ositive breast cancer. Radiation and surgery are currently the main local treatment ...
Brain metastases from cancer cervix are extremely rare. We report a patient with squamous cell carcinoma of the cervix in a rural setting in western Maharashtra who developed an isolated right parafalcine high frontal metastasis within 6 months of treatment of the primary disease. The presenting sy...