The tendency of tumors to metastasize varies for one tumor type to another for the same type of tumor. The tendency to develop BM may not only depend on risk factors such as stage, grade, and histology, but also on the genetic profile of the primary tumor. The study suggests that ...
guidance molecules via paracrine signaling to drive neuron reprogramming, and thereby recruit the nerves or invade the existing nerves; (ii) nerves can also secrete neuroactive molecules to interact with the receptors of tumors or the TME for the tumor cells to proliferate, invade, and metastasize....
"Breast cancer is one of the most common tumors to metastasize to the brain. Breast cancer brain metastases worsen prognosis, negatively affect quality of life, and currently available treatments are limited," said Melanie Hayden Gephart, MD, professor of Neurosurgery at Stanford Medicine, co-...
mCRPC is the state of prostate cancer that continues to progress and metastasize despite receiving ADT. Current treatment options for mCRPC include hormone therapy (enzalutamide, abiraterone, and apalutamide), chemotherapy (docetaxel and cabazitaxel), immunotherapy (sipuleucel-T), targeted therapy (PARP...
and successfully metastasize here. In some studies, multiple miRNAs have been shown to promote cancer metastasis. The following is a partial summary. Upregulation of miR-10b, although not affecting cancer cell proliferation, promotes migration and invasion of breast cancer cells [87]. An experiment...
This population of tumor cells prefers to develop brain metastases [37]. Also, EGFR ligand HBEGF and COX2 were two regulators identified in metastatic models that selectively metastasize to the brain [38]. It suggests that analyzing the gene expression pattern on CTCs can evaluate the destination...
Chemotherapy kills cells that divide more frequently, therefore cancer cells are hit the hardest Which of the following is not a route where cancer cells can metastasize?A. TranscoelomicB. LymphaticC. TransdermalD. Haematogenous C. Transdermal In which of these mechanisms of spread can the cancer...
A substantial number of studies have provided compelling evidence of organotropism, a non-random process where tumor cells preferentially metastasize to specific organs [42]. This complex process is regulated by several key components, including tumor cellular structure, the microenvironment composition of...
[65].MUC1is one of the cell surface molecules that the immune system first encounters. It can activate CTLs to kill tumor cells expressingMUC1. The PDTRP site in the VNTR domain is recognized by both B cells and T cells [66,67].MUC1can undergo quantitative and qualitative changes ...
Colorectal cancer is the second-leading cause of cancer death in men and women combined in the United States. It metastasizes most often to the liver. Rarely, it metastasizes to the brain, where it is almost always fatal. The initial changes to the genome that cause cancer are called drive...