The molecular basis for breast cancer metastasis to the brain is largely unknown1,2. Brain relapse typically occurs years after the removal of a breast tumour2,3,4, suggesting that disseminated cancer cells must acquire specialized functions to take over this organ. Here we show that breast canc...
Long-term survival in a patient with brain metastases preceding the diagnosis of endometrial cancer 鉁Only five patients found to have brain metastasis preceding the diagnosis of endometrial cancer have been reported in the literature, and none of these ... E Petru,S Lax,S Kurschel,... - 《...
内容提示: LETTERSGenes that mediate breast cancer metastasisto the brainPaulaD.Bos 1 ,XiangH.-F.Zhang 1 ,CristinaNadal 1 {,WeipingShu 1 ,RogerR.Gomis 1 {,DonX.Nguyen 1 ,AndyJ.Minn 2 ,Marc J. van de Vijver 3 , William L. Gerald 4 , John A. Foekens 5 & Joan Massague ´ 1...
Using tumor DNA methylomes to predict cancer metastasis to the brain Metastatic spread of cancer to the brain has a devastating effect on patient outcomes, yet identifying patients who will develop brain metastases is difficult in current clinical practice. We show that DNA methylation signatures from...
Using brain metastasis mouse models, researchers showed that when the astrocytes were exposed to cancer cells, they began to activate type Iinterferonpathways. Type I interferon, the cytokines associated with regulating inflammation, have been shown to have to anti-tumor effects. However, more and ...
Background: Metastasis of gastric carcinoma to the brain is very uncommon. At The University of Texas M. D. Anderson Cancer Center (M. D. Anderson), less than 1% of patients with primary gastric carcinoma are found to have brain metastases. Little has been published regarding the evaluation ...
SHuzie: A Memoir: My Journey of Lung Cancer to Brain Metastasisby Sherry Lyn Guarneri
Brain metastasis is an increasingly common complication for breast cancer patients; approximately 15– 30% of breast cancer patients develop brain metastasis. However, relatively little is known about how these metastases form, and what phenotypes are characteristic of cells with brain metastasizing potent...
Nerve cells in the brain and throughout the body can turbocharge tumor growth — a finding that not only expands conventional ideas about the nervous system but points to novel therapeutic targets for a range of malignancies.大脑和全身的神经细胞可以加速肿瘤生长--这一发现不仅拓展了人们对神经系统的...
Nodes (N): Spread of cancer to lymph nodes in the regional area of the primary tumor Metastasis (M): Spread of cancer to distant sites away from the primary tumor Some cancers, including those of the brain, spinal cord, bone marrow (lymphoma), blood (leukemia), and female reproductive sy...