cellular senescence, and notch signaling pathways. Similarly, EV-coupled miRNAs released from thermally stressed organoids showed their potential regulation of genes involved in cellular senescence, p53 signaling, and TGF-beta signaling pathways. Conclusions In conclusion, the cellular and extracellular resp...
DHA supplementation also increased progesterone and estradiol secretion, together with the protein expression level of the steroidogenic enzymes HSD3B1, CYP11A1 and the cholesterol transporter StAR. Such increase in progesterone level is also reported after in vivo n-3 enriched diet supplementation of ...
In human GCs, TGF-β1 was shown to decrease progesterone production and STAR expression via the ERK1/2 signaling pathway [11]. In bovine TCs, luteinizing hormone (LH) was shown to stimulate androgen production and CYP17A1 expression via the activation of the PI3K/AKT pathway [12]. Our ...
TGFB1 Activation Reagent Real Time PCR Experimental Service Streptavidin Fast blue Protein Stain solution Single-component Reagents of FLIA Kit Streptavidin-Agarose Beads MagazineCitations The International Journal of Biochemistry & Cell BiologyChanges of hepatic lactoferrin gene expression in two mouse models...
The most significant upstream regulators that were cell signaling molecules were KITLG (6 genes), TGFB1 (17 molecules) and TNFA (13 molecules). Among all genes in the DKK1 group, 3.3% (159/4858) were significantly (P < 0.05) correlated with embryo length, with 133 genes being ...
(also known as GLUT4);VEGFA, vascular endothelial growth factor A;KDR, kinase insert domain receptor/VEGF receptor 2;TGFB1, TGF-β1;FGF2, fibroblast growth factor 2;IGF, IGF;ANGPT1, angiopoietin 1;ANGPT2, angiopoietin 2;TIE1, tyrosine kinase with immunoglobulin like and EGF like domains...
ACVR1B is a member of the TGF-β pathway, which transduces extracellular signaling into the cytoplasm [38]. TGF-β inhibits myogenesis through inhibiting the expression and function of MRFs. It has been shown that TGF-β reduces the expression of myogenin and myocyte enhancer factor 2D (MEF2D...
Ovarian granulosa cells (GCs) under the action of FSH [1] produce peptide hormones of the transforming growth factor beta (TGF-β) superfamily. These hormones, including the inhibins, i.e., inhibin α subunit (INHA), inhibin β subunits (INHβA and INHβB), and activins [2,3], hav...
Ovarian granulosa cells (GCs) under the action of FSH [1] produce peptide hormones of the transforming growth factor beta (TGF-β) superfamily. These hormones, including the inhibins, i.e., inhibin α subunit (INHA), inhibin β subunits (INHβA and INHβB), and activins [2,3], hav...
Apart from the above hormones, the steroid hormones (including estradiol and progesterone), members of TGF-β (transforming growth factor-β) super family (including activins and inhibins) and other factors secretion by GCs are also critical for maintenance of the ovarian cycle [12]. Progesterone...