Plasma cells, including a long-lived subset, reside in the bone marrow where they depend on poorly defined microenvironment-linked survival signals1. We show that bone marrow plasma cells use the ligand-gated purinergic ion channel P2RX4 to sense extracellular ATP released by bone marrow ...
TABLE 16.1 Indications for Bone Marrow Trephine Biopsies Assessment of patients with unexplained blood cytopenias or increased cell counts Suspected diagnoses of lymphoma, leukemia, myeloproliferative or myelodysplastic syndromes, lymphoproliferative disorders, plasma cell dyscrasias, and metastatic tumor Monitoring...
(1984), BONE MARROW PLASMA CELL INFILTRATION IN MULTIPLE MYELOMA. British Journal of Haematology, 57: 352–353. doi: 10.1111/j.1365-2141.1984.tb02906.x Author Information Institute of Haematology ‘Lorenzo e Ariosto Seràgnoli’, S. Orsola's Hospital, University of Bologna, and Chair of ...
plasma cellsbone marrowintravital imagingmigrationCXCR4APRILVLA-4antibody secreting cellsCXCL12Using intravital imaging, we report that bone marrow (BM) plasma cells (PCs) are motile. BM PCs exhibit a unique migration pattern, characterized by intermittent periods of high motility and longer stretches ...
Multiple myeloma is a B cell malignancy characterized by clonal expansion of malignant plasma cells within bone marrow. More than 80% of patients with myeloma develop lytic lesions in bone, thereby causing pathologic fractures, severe bone pain, spinal cord compression, and hypercalcemia7. Myeloma-in...
This system is easy to assemble and facilitates the premixing of bone graft materials with intravenous fluids, blood, plasma concentrate, platelet rich plasma, bone marrow, or other specified blood components as deemed necessary by the clinical use requirements. Download Brochure Fill Allows simple ...
product name:Human Mantle Cell Lymphoma Bone Marrow Plasma (Newly Diagnosed/Untreated); cat no:ABC-TC3887; Size/Quantity:1 vial; Biosafety Level:1; Shipping Info:Dry Ice; Storage:Liquid Nitrogen; Description:Mantle Cell Lymphoma-Plasma is obtained by centrifugation of blood tissues. Mantle Cell ...
Effects of the exosomes derived from bone marrow mesenchymal stem cells (BMSC-Exos) on BMECs. A Cell Counting Kit-8 assays were used to assess the proliferation ability of BMECs. B Cell scratch assays were used to assess the migration ability of BMECs. C Flow cytometry was used to analyze...
Subchondral bone marrow lesions A bone marrow lesion (BML), or so-called “bone marrow edema”2or “bone marrow edema-like abnormality”,3describes a noncystic, ill-defined, high-signal area on T2-weighted or proton density-weighted MRI.4BMLs are divided into the subchondral type and ligament...
Cell surface LRP6 is reduced in bone marrow MSCs under microenvironment of high oxPLs We examined whether increased oxPL production in bone marrow microenvironment leads to functional decline of bone marrow mesenchymal stromal cells (MSCs). Bone marrow MSCs from mice fed a Western high fat diet (...