It is used as a first-line treatment for MM, along with dexamethasone.#To investigate the effects of LEN on the function of bone marrow (BM) by monitoring the changes in the number of white blood cells (WBCs), hemoglobin levels, and platelet counts in people who were getting treatment.#...
34,35. The osteoblasts formed by LepR+cells contribute to the maintenance and repair of the adult skeleton33,34,36and secrete factors that promote osteogenesis22,23. The adipocytes that arise from LepR+cells in adult bone marrow promote the regeneration...
The effects of romiplostim on bone marrow morphology were evaluated in adults with immune thrombocytopenia (ITP). Patients with platelet counts 9/L, ≥1 prior ITP therapies, and no collagen at baseline received weekly subcutaneous romiplostim starting at 1μg/kg, adjusted to maintain platelet ...
To investigate the role of co-stimulatory and co-inhibitory molecules on immune tolerance in immune thrombocytopenia (ITP), this study mapped the immune cell heterogeneity in the bone marrow of ITP at the single-cell level using Cytometry by Time of Flight (CyTOF). Thirty-six patients with ITP...
Generalized bone marrow hypoplasia reduces quantities of granulocyte progenitor cells along with the other hematopoietic cell lines. Bone marrow hypoplasia can occur because of a variety of processes, including infectious diseases, exposure to some drugs and toxicants, radiation, myelophthisis, and c...
Using bone marrow smears of the type prepared routinely in clinical practice, we determined megakaryocyte ploidy distributions in five normal persons, eight patients with both normal platelet counts and normal bone marrow morphology, and 18 patients with quantitative platelet disorders. To include 2N and...
To investigate the effect of bone marrow mesenchymal stem cells (MSC) on hematopoietic recovery and acute graft-versus-host disease (GVHD) in a murine allogeneic umbilical cord blood transplantation (allo-UCBT) model. MSCs were obtained from C57/BL mouse bone marrow. The MSC phenotypes were iden...
In 18 patients with decreased platelet production proved by reduced platelet turnover, the numbers of megakaryocytes in clot section of marrow aspirate were counted. Platelet counts ranged from 19,000 to 128,000/microliters. The sternal marrow showed decrease of megakaryocytes only in 3 out of ...
Objective To clarify the curative significance of bone marrow megakaryocyte counts in patients with idiopathic thrombocytopenic purpura in order to serve as the basis for its treatment.Methods 126 patients were classified into two groups according to their megakaryocytic counts on bone marrow smears (77...
Protection by WR-2721 of bone marrow (BM) from depression following hemibody irradiation (HBI) was assessed in patients receiving palliative therapy for widespread symptomatic metastasis on a Phase I/II Radiation Therapy Oncology Group (RTOG) protocol. Twenty-five patients are currently evaluable for...