Bone marrow clot section (a) and smear (b) from a case of acute lymphoblastic leukemia with t(4;11). The blasts are of various sizes and show scanty cytoplasm. – High leukocyte count, often ≥200,000/μL – Early precursor B-cell type with lack of expression of CD10 and CD20 (...
Table 6. Summary of clinical and bone marrow features of 4 new patients presenting with pancytopenia that were positive for GATA2 mutations FeaturesP1, 43/FP2, 24/FP3, 28/FP4, 36/M Hemoglobin (g/dL, normal 13.7-17.5 g/dL) 11.3 9.9 11.4 10.7 Platelet count (K/μL, normal 161-347 K...
To the editor,We read the article by Lee and colleagues with great interest [3].Although the authors found that the combination of bone marrow aspirate concentrate (BMAC) and platelet-rich plasma (PRP) enhanced bone healing, it remains unclear which factor produces this effect because they were...
To investigate the role of co-stimulatory and co-inhibitory molecules on immune tolerance in immune thrombocytopenia (ITP), this study mapped the immune cell heterogeneity in the bone marrow of ITP at the single-cell level using Cytometry by Time of Flight (CyTOF). Thirty-six patients with ITP...
In comparison, mean platelet volume during bone marrow recovery increased in 12 cases of the 18 patients studied. We conclude that flow cytometric analysis of reticulated platelets is a sensitive and specific test for evaluating thrombopoiesis recovery during aplastic chemotherapy, and platelet ...
Bone marrow transplantation may lead to a complete recovery in children with aplastic anaemia, acute leukemia and severe combined immunological deficiency. The history of bone marrow transplantation...doi:10.1007/978-94-009-7520-0_31J. de Koning...
Bone Marrow Steven H. Kroft Alexandra M. Harrington Robert W. McKenna THE BONE MARROW BIOPSY PROCEDURE The bone marrow biopsy is a routine technique in the diagnosis of hematologic disorders, metastatic tumors, and infectious and metabolic diseases. Expe
familialplatelet disordersis associated with the development of additional cytopenias, multilineage dysplasia, cytogenetic abnormalities,somatic mutations, ringed sideroblasts or increased blasts. Flow cytometry analysis can be diagnostically helpful in discriminating different etiologies of marrow failure [4]. ...
De Oliveira et al. studied the regenerative results of the addition of bone marrow aspirate concentrate, using a single or double centrifugation protocol, to a xenogeneic bone graft in sinus floor elevation. This pilot study indicates that the clinical use of bone marrow aspirate concentrate, obtain...
a process ofdose titrationis essential, and treatment should be withheld if the platelet count falls below 100,000. Patients withmultiple myelomaandchronic lymphocytic leukemiaappear to exhibit greaterhematologic sensitivity to TBI than those with normal bone marrow, and death has resulted even after ...