LDL, HDL and triglyceride testing only tells part of the story when it comes to heart disease risk. The NMR LipoProfile® test provides these standard lipid tests along with LDL and HDL particle values, plus risk assessment for insulin resistance. Using state of the art technology known as ...
forming the inner part of the BBB [19]. Tight junction proteins provide a tightness necessary for physiological barrier function. They prevent paracellular diffusion of ions and small molecules
The blood–brain barrier (BBB) is a sophisticated structure whose full functionality is required for maintaining the executive functions of the central nervous system (CNS). Tight control of transport across the barrier means that most drugs, particularl
in the assembling of the glioblastoma neurovascular model, it is possible to observe an increased aggressiveness of the model implanted tumor in the presence of the BBB. This way, it shows the significance of having neurovascular models even for the in vivo-like behavior of an in vitro grown t...
This rate decreases with decreasing levels of LDL in plasma; by extrapolation to zero net rate it can be tentatively suggested that transfer of this cholesterol-rich particle into the artery becomes very small when plasma LDL cholesterol concentration is in the range 40–80 mg/dl. Recent studies...
Student test or one-way analysis of variance (ANOVA) followed by Dunnett post hoc test were used to determine the significant difference at P-value of less than 0.05. 3. Results 3.1. Isolation and characterization of Exos Macrophages are one of the sources of the exosomes. The THP-1 cells...
Blood–brain barrier (BBB) is a natural protective membrane that prevents central nervous system (CNS) from toxins and pathogens in blood. However, the presence of BBB complicates the pharmacotherapy for CNS disorders as the most chemical drugs and bioph
Post-hoc t–tests were performed if a main effect was found using Tukey’s HSD correction for multiple comparisons. The relationship between baseline FMD and baseline retrograde shear in patients and controls was tested with Pearson’s correlation test. The impact of retrograde shear stress on FMD...
Both PLS-DA models show a moderate classification power with misclassification rates of 17 and 30% and AUC of 0.75–0.89 for training and test set models, respectively. *LV latent variables, VIP variable importance projection, LDL low-density lipoprotein, Chol cholesterol, HDL high-density ...
The LDL-induced stimulation of pericyte proliferation was thought to be activated by T-cadherin-mediated activation of Erk1/2 tyrosine kinase and translocation of NF-κB in the nucleus (Takeuchi et al., 2007; Takeuchi & Ohtsuki, 2002). Activated pericytes then may contribute to calcification and...