With the development of geroscience and the rise of blood biomarkers, there has been a paradigm shift from disease prevention and cure to promoting health and healthy aging. New -omic technologies have played a role in the development of blood biomarkers, including epigenetic, proteomic, metabolomic...
Blood-based biomarkers hold great promise to revolutionize the diagnostic and prognostic work-up of Alzheimer’s disease (AD) in clinical practice. This is very timely, considering the recent development of anti-amyloid-β (Aβ) immunotherapies. Several assays for measuring phosphorylated tau (p-tau...
A variety of biomarkers,quantitative physiological indicators of health status, can be used to assess individual biological aging rates and health risks2,3. These metrics aid the diagnosis and prognosis of diseases associated with aging, such as cancer4 and genetic diseases that result in premature ...
Blood-based biomarkers of adverse perinatal outcomes in maternal obesity Conclusion: There is a critical need for reliable blood-based biomarkers associated with an increased risk of adverse perinatal outcomes in obese pregnant ... TT Herrera,JL Garcia,GB Britton - The journal of maternal-fetal & ...
Identifying a biomarker for Alzheimer's disease that can be obtained from a blood sample has been a goal of researchers for many years. Over the past few years a number of investigators have studied several plasma biomarkers but most frequently plasma amyloid beta (Aβ)40 and Aβ42 while oth...
"Is this ageing or a new way to detect early age-related disease biomarkers? The authors favour the former, I don't think the latter is ruled out," he said. Dr Wyss-Coray said: "If we can reproduce this finding in 50,000 or 100,000 individuals it will mean that by monitoring the...
[30], were built to predict biological age utilizing biomarkers and chronological age; while the 3rd generation clock DunedinPACE [31] was built to predict the pace of aging, utilizing longitudinal biomarker and health data, and not chronological age as such. Horvath was trained with blood and ...
Pathogen load was related to different sets of age-related physical and cognitive measures of functional aging and the Frailty Index (FI), and plasma levels of biomarkers of inflammation, innate and adaptive immunity, and other physiological functions.Results: High pathogen load was associated with ...
Differential miRNAs can be recognized and possible biomarkers can be identified by sequencing and comparison with known abundance mRNA [68]. It was concluded that hsa-mir-140-5p, hsa-mir-362-5p, hsa-mir-590-3p, hsa-mir-210 and hsa-mir-671-3p were potential biomarkers for blood stasis ...
Cerebrospinal fluid (CSF) and PET markers of amyloid-β and tau proteins are accurate in detecting the neuropathological changes of Alzheimer disease (AD). The use of CSF and PET biomarkers is limited by invasiveness or high costs; to address these issues, blood-based AD biomarkers are eagerl...