[payload:topoisomerase I (Top I)抑制剂;喜树碱] BL-M11D1采用DAR10定点偶联。 研发机构 百利天恒 最高研发阶段 全球: I期临床 中国: I期临床 审评审批类型 -- 外置链接 -- 了解药物更多情报 登录查看 生物序列 研发时光轴 交易&权益 疾病 获批适应症 中国研发进度 临床结果 临床试验 ...
BL-M11D1 achieves a high drug-to-antibody-ratio (DAR=8) with a highly stable linker and is readily internalized and trafficked to lysosomal cellular compartments. The antitumor efficacy of BL-M11D1 was evaluated in xenograft tumor models. BL-M11D1 exhibited strong tumor inhibition capacity...