Biotin-tagged photoaffinity probeLigand-protein interactionVascular endothelial growth factor receptor-2VEGFR-2Chemical proteomics is a branch of proteomics in order to decipher protein function and mechanism at the level of directly observed protein-ligand(or small molecule)interactions by using chemical ...
Design and synthesis of a biotin-tagged photoaffinity probe of paeoniflorin.[J].Bioorganic and Medicinal Chemistry Letters 2006,12(12).Wen-Wei Qiu,Jie Xu,Da-Zhi Liu,Jing-Ya Li,Yang Ye,Xing-Zu Zhu,Jia Li,Fa-Jun Nan.Design and synthesis of a biotin-tagged photoaffinity probe of paeoniflorin...
The results suggest that photoaffinity probe 4 specifically recognizes tubulin at the same binding site as anticancer drug candidate 1, and this leads to the disruption of microtubules. Probe 4 serves well as a useful chemical probe for potent antimicrotubule diketopiperazines, much like phenylahist...
Our versatile dual-display phage exhibits high flexibility; by swapping the displayed peptide/probe, one can change the phage target while retaining the sBT gene in-frame with the pIII. We expect the generated biotin-tagged dual phages to be used as a multifunctional probe to couple with ...