In this study, we describe a patient with unusual TFT results due to biotin interference.Jeffrey Sung-Shing KwokIris Hiu-Shuen ChanMichael Ho-Ming ChanPathologyKwok JS, Chan IH, Chan MH (2012) Biotin interference on TSH and free thyroid hormone measurement. Pathology 44: 278-280. [Cross...
Interference caused by biotin ingestion has now been widely reported, with several clinical consequences [10]. Commonly affected parameters are cardiac markers (Troponin T and I) and hormone parameters, such as TSH, FT4, FT3, 25OHD, and PTH [6], [7], [21], [22], [23]. Herein, we ...
Among the 23 biotinylated assays studied, biotin interference was of greatest clinical significance in the OCD Vitros TSH assay, where falsely decreased TSH concentrations (to <0.15 mU/L) could have resulted in misdiagnosis of thyrotoxicosis in otherwise euthyroid individuals. Likewise, falsely decreased...
Most of the published research on biotin interference covers hormone tests, such asparathyroid hormone (PTH),thyroid stimulating hormone (TSH),T4andT3tests, as well as tests for troponin. However, because biotin is used in so many immunoassays, scientists say it could interfere with many others....
To assess whether biotin supplements cause interference in routine clinical laboratory testing of thyroid stimulating hormone (TSH), free triiodothyronine (FT3), free thyroxine (T4), parathyroid hormone (PTH) troponin-T and N-terminal pro b-type natriuretic peptide (NTproBNP). Three adult volunteers...
Clinicians need to be aware of the effects of biotin on a wide variety of laboratory measurements and take precautions to avoid errors related to biotin interference. This can require an intentional approach, including close scrutiny of all supplements utilized by their patients as the biotin ...
False negative, as well as false positive results, have been reported for thyroid hormone, TSH, and serum troponin. The FDA is advising health care providers to ask patients if they are on biotin containing supplements and to consider biotin interference as a possible source of error if test ...
The clinical risk resulting from biotin interference depends upon the analytical bias caused by biotin (e.g. when the result is near a medical decision point), clinical application of the test, and consequences of a false-positive or false-negative result for a given patient [5]. Therefore, ...
Together with the fact that mutations in the gene for Pit-1/GHF-1 resulted in the combined deficiencies of TSH, GH and PRL in mouse, we conclude that the combined hormone deficiencies of the patient is ascribed to the nonsense mutation of the PIT1 gene. A 32 MOLECULAR ANALYSIS OF ...
QUESTION: How does the potential for biotin lab interference affect pharmacy practice and its role in patient care? The patient in the above case is taking a high dosed biotin supplement and had tests of concern. Her low TSH and high T4 could be associated with biotin use, especially if she...