Denoising diffusion models embody a type of generative artificial intelligence that can be applied in computer vision, natural language processing and bioinformatics. In this Review, we introduce the key concepts and theoretical foundations of three diff
To import the images into MATLAB R2018b, we used the toolbox Bioformats59. To distinguish movement of the entire cell or nucleus from movement of actin, the images were stabilized with the option ‘translation’ using the Zeiss Zen function ‘time alignment’ on the signal of the nuclear ...
29, which suggested that the antiviral drug plitidepsin may have an ideal effect on elderly patients and infants30. However, this speculation was based on the drug target. Due to the unique pharmacokinetics in infants, we could not give definitive...
A possible option to explore in future will be to enhance the expression level of various rate limiting steps to enhance the production of terpenes. Figure 5 Expression level of unigenes involved in MEP pathway. The number in green represents the expression level of a particular unigene in PGT...
Amplification of the centromeric (Cen-524) and telomeric (Tel-190) sequences was conducted using the primers listed in the Additional file2: Table S7. The purified PCR products of Cen-524 and Tel-190 were labeled with Cy5-dUTP and FITC-dUTP using Nick Translation Mix (Roche, Mannheim, Ger...
The RNA-binding protein Gemin5 binds directly to the ribosome and regulates global translation. Nucleic Acids Res. 2016;44:8335–51. Article PubMed PubMed Central CAS Google Scholar Shi M, Zhang H, Wu X, He Z, Wang L, Yin S, Tian B, Li G, Cheng H. ALYREF mainly binds to the ...
translation in the nucleus. We speculate that mRNA cap formation and polyadenylation evolved originally for this purpose: tagging certain transcripts for translocation through the nuclear pore and limiting intranuclear translation. It is noteworthy that, in some systems, mRNA processing [148],[149] and...
The essential steps in the calculations reported here are 1) defining standard states, 2) identifying model proteins for systems of interest, 3) assessing the relative abundances of model proteins in metastable equilibrium, 4) visualizing the results of the calculations on chemical diagrams and 5) ...
translation and an increase in the transcription of genes involved in signaling cascades. At later time points, condition-dependent metabolism was revealed. For example, protein degradation and energy metabolism derived from amino acids occurred in warm temperatures and darkness. Amino acid catabolism ...
Similar to the biofilm experiment, steps 2–6 are defined as a series of cycles, and the planktonic evolution experiment is performed for 10 cycles. The last cycle was stopped at step 5. Each planktonic sample is stored at −80 °C and characterized later, as well as biofilm samples....