What is the translation process? Understand the process of translation. Learn what happens during the initiation, elongation, and termination phase...
The endoplasmic reticulum (ER) coordinates mRNA translation and processing of secreted and endomembrane proteins. ER-associated degradation (ERAD) prevents the accumulation of misfolded proteins in the ER, but the physiological regulation of this process remains poorly characterized. Here, in a genetic ...
Our current and prior findings highlight how chemical modifications of mRNA tune the dynamics of protein synthesis at different steps of translation elongation.This is a preview of subscription content, access via your institution Access options
Light activates the differentiation of etioplasts into chloroplasts in a process that is accompanied by a large and coordinated increase in the biosynthesis and accumulation of carotenoids, chlorophylls and pigment-binding proteins; this accumulation supports the development of a functional photosynthetic ap...
(position 20,875,691) was detected via Sanger sequencing in theTcMYB1135' untranslated region (UTR), located 25 bases upstream of the ATG start site (see Additional file1, Table S23). The function of this SNP is difficult to infer; however, mutations occurring near translation start sites ...
and translation. Stressor-specific responses were also apparent. Ibuprofen and other NSAIDs are known anti-inflammatory agents; we therefore expected responses in genes such as CLECT (encoding C-type lectin like) that are involved in the immune system (Table1[section 4.4]). More importantly, a...
The fact that incoherent FFL is missing in our cancer regulation network may imply an important and specific aspect of cancer cells. While the overall working pipeline turns out to be effective in this work, some specific steps need to be discussed. For example, the prefiltration step (...
Transcription, the synthesis of RNA from DNA. Genetic information flows from DNA into protein, the substance that gives an organism its form. This flow of information occurs through the sequential processes of transcription (DNA to RNA) and translation (
In both UK Biobank release v3 and our NewMood database, genetic variants were restricted to biallelic single-nucleotide polymorphisms (SNPs), analyzing directly genotyped and imputed variants as well. QC steps are detailed in Supplementary File S1. 2.4. Analyses Descriptive statistical analyses, as...
(Oxford Nanopore) with default parameters. Two trimming steps were employed. Adapter sequence was first trimmed by porechop (version 0.2.4) (https://github.com/rrwick/Porechop) with parameters “--check_reads 10000 --adapter_threshold 100 --end_size 100 --min_trim_size 5 --end_threshold ...