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As a data scientist, you often need to extract data that is publicly available on the Internet in the form of a PDF document, HTML webpage, or a Tweet. You will not always be presented with clean, formatted data in a CSV file or Excel sheet. By the end of this course, you will ...
Finally, we studied examples of complexes containing IDPs/IDRs that adopt a stable structure upon binding. IDRs often bind through short linear motifs (SLiMs), recognizing folded domains driven by a few residues. The longer IDRs can contain arrays of SLiMs and can also form stable structures upo...
YAP-MAMLD1 concentrates transcription factors and co-activators, including BRD4, MED1 and TEAD, in condensates while excluding transcriptional repressive PRC2, and induces long-range enhancer–promoter interactions that promote transcription and oncogenic programmes. Blocking condensate-mediated transcriptional...
They should avoid introducing new facts in the form of unpublished data or personal communications. Thus, the reader will be able to assess the interpretations and evaluate the methodology employed in the publications that are cited in the review. The Introduction should outline the scope of the...
The graphical abstract should summarize the contents of your article in a concise, pictorial form which is designed to capture the attention of a wide readership. A graphical abstract will help draw more attention to your online article and support readers in digesting your research. Some guidelines...
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Cell-free formation of RNA granules: low complexity sequence domains form dynamic fibers within hydrogels. Cell 149, 753–767 (2012). This paper reconstituted RNA granules in vitro and revealed the role of LCDs in driving liquid-to-solid phase separation. Bose, M., Lampe, M., Mahamid, J....
The nascent cells of the ICM segregate to form the primitive endoderm (PrE) and the epiblast. These intricate processes, which are fundamental to early embryonic development, have historically been difficult to study in depth. However, recent advances in stem cell research have now made it ...