The UK Biobank (UKB)3documents phenotypic variation of 500,000 participants across the UK, with a healthy volunteer bias4. The UKB whole-genome sequencing (WGS) consortium is sequencing the whole genomes of all the participants to an average depth of at least 23.5×. Here we report on the ...
While volunteer-based studies such as the UK Biobank have become the cornerstone of genetic epidemiology, the participating individuals are rarely representative of their target population. To evaluate the impact of selective participation, here we derived UK Biobank participation probabilities on the ...
We then apply the model to a healthy population in the UK Biobank study to identify a cohort at risk for Alzheimer’s disease. Results We show that the cohort with a neuroimaging Alzheimer’s phenotype has a cognitive profile in keeping with Alzheimer’s disease, with strong evidence for ...
Clinical biomarker-based biological ageing and future risk of neurological disorders in the UK Biobank Background Many common neurological disorders are associated with advancing chronological age, but their association with biological age (BA) remains poorl... JKL Mak,CE Mcmurran,S Hagg - 《Journal...
We use state-of-the-art techniques to preserve cells in a way that maintains viability, allowing them to be thawed years into the future in a living state. These samples can then be used to establish pregnancies through advanced assisted reproductive technologies (aARTs), restoring genetic diversi...
In the UK Biobank, trained nurses interviewed participants about their regular medication use [35]. Interviewers asked participants to provide names of all regular medications they were taking and retrieved each response from a list of generic and trade names of medications available in the UK. Any...
Bristol Myers Squibb is one of nine pharma companies in a consortium under the UK Biobank, which plans to release the genetic sequencing data of 500,000 participants in the UK. The data for the first 200,000 was recently released.
Deep genome-wide profiling has increasingly become a standard measurement in established cardiovascular population cohorts and in emerging precision medicine biobanks. In this issue ofJAMA Cardiology, Lyall et al1harness genetic and clinical information from the UK Biobank to demonstrate a causal associati...
Cancer biobanks have a crucial role in moving forward the field of translational cancer research and, therefore, have been promoted as indispensable tools for advancing basic biomedical research to preclinical and clinical research, ultimately leading to the design of clinical trials. Consequently, they...
Purchase document Association of ultraprocessed food consumption with risk of microvascular complications among individuals with type 2 diabetes in the UK Biobank: a prospective cohort study The American Journal of Clinical Nutrition Volume 120, Issue 3,September 2024, Pages 674-684...