The UK Biobank is an unprecedented resource for human disease research. In March 2019, 49,997 exomes were made publicly available to investigators. Here we note that thousands of variant calls are unexpectedly absent from this dataset, with 641 genes showing zero variation. We show that the ...
The Pharma Proteomics Project is a precompetitive biopharmaceutical consortium characterizing the plasma proteomic profiles of 54,219 UK Biobank participants. Here we provide a detailed summary of this initiative, including technical and biological valid
Clinical laboratory tests are a critical component of the continuum of care. We evaluate the genetic basis of 35 blood and urine laboratory measurements in the UK Biobank (n = 363,228 individuals). We identify 5,794 independent loci associated with at least one trait (p < 5 ×...
HreIsGeaHrcLhIGHTS a powerful way to link genetic and epidemio logical factors to disease risk DISEASE GENETICS UK Biobank — a new era in genomic medicine Population-based 'biobank' studies are a powerful way to link genetic and epidemiological factors to disease risk. The UK Biobank is ...
Before it has even begun recruiting participants, the UK Biobank project has raised extraordinary passions among scientists. Some scientists are broadly supportive of the project, and feel that it is a scientifically valid, potentially valuable resource, although they still have reservations over the de...
By integrating their findings with data from the UK Biobank, the researchers discovered the most common risk genes for multiple sex-biased diseases. Additionally, some of the genes showed sex differences or were androgen-responsive, according to the study.■...
According to the UK biobank[23], Mendelian randomization analyses support a causal association between higher BMI and mortality from CHD (HR: 1.12; 95% CI: 1.00–1.25). Importantly, veterans differ from other populations of patients in several other respects. One of the most prominent differences...
In 202,702 participants aged ≥ 60 years from the UK Biobank, Cox proportional-hazards models were used to examine the associations between eGFR and urine albumin creatinine ratio (ACR) with risk of incident dementia. GFR was estimated based on serum creatinine, cystatin C, or both. The ...
Associations between alcohol consumption and gray and white matter volumes in the UK Biobank. Nat Commun. 2022;13:1175. CAS PubMed PubMed Central Google Scholar Simon J, Fung K, Kolossváry M, Sanghvi MM, Aung N, Paiva JM, et al. Sex-specific associations between alcohol consumption, ...
Cardiometabolic diseases are the leading cause of death worldwide. Despite a known genetic component, our understanding of these diseases remains incomplete. Here, we analyzed the contribution of rare variants to 57 diseases and 26 cardiometabolic traits