Association of resting heart rate with cognitive decline and brain age in older adults: a large‐scale cohort study in the UK Biobankdoi:10.1002/alz.075211Wang, JiaoYang, WenzheDove, AbigailQi, XiuyingXu, WeiliAlzheimer's & Dementia: The Journal of the Alzheimer's Association...
However, no study has yet used path analysis to examine the mediating role of physical activity, morning wake-up time, and sleep-inducing medication in the relationship between age and depression. Methods This path analysis study utilized data from the baseline phase of the Ravansar non-...
12. Sedentary behaviour has been independently linked with cognitive decline in older adults, including through vascular risk factors15. However, other sedentary activities such as using the internet
represents a comprehensive assessment of aging. It surpasses chronological age in its predictive ability for age-related diseases and mortality risks. Compared to chronological age, which simply counts the passage of time since birth, BA integrates complex factors such as genetic...
Age is the key risk factor for diseases and disabilities of the elderly. Efforts to tackle age-related diseases and increase healthspan have suggested targeting the ageing process itself to ‘rejuvenate’ physiological functioning. However, achieving thi
Thus, in a rapidly aging society, research into the mechanisms underlying aging can provide insights into how to extend healthy longevity by delaying the onset of age-related diseases. Biological aging is an increase in the rate of decline in physiological systems and functional ability that ...
Altered transcriptional and epigenetic regulation of brain cell types may contribute to cognitive changes with advanced age. Using single-nucleus multi-omic DNA methylation and transcriptome sequencing (snmCT-seq) in frontal cortex from young adult and aged donors, we found widespread age- and sex-re...
(physical, emotional, and sexual), neglect (physical and emotional), and family dysfunctions, are significantly correlated with later cognitive impairments.Citation9–11Negative Life Events (NLE), such as severe illness, and financial problems, may be associated with increasing cognitive decline in ...
Inflammation and oxidative stress Inflammation is the basis of aging and many age-related chronic diseases, which in turn increase the rate of aging. Walker et al. examined the association between systemic inflammation measured during midlife and 20-year cognitive decline within the Atherosclerosis Risk...
Additionally, GDF-15 levels were linked to markers of impaired glycemic control, systemic inflammation, and physical decline, including decreased lung function and grip strength, especially in men. These findings highlight the use of GDF-15 as a biomarker for aging and age-related functional ...