Selection weights were constructed in AOU and MGI to make them more representative of the US adult population, using data from the 2019 National Health Interview Survey; previously described weights for the UKB were used. We estimated phenomewide prevalences, pairwise correlations, and phenome ...
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ABSTRACT. Research on cognitive function in individuals with chronic kidney disease (CKD) is critical due to the significant public health challenge posed
(IBD) detection, and haploid imputation. When applied to the UK Biobank dataset, this allows us to infer the PofO for 21,484 samples with high confidence in addition to the 4909 duos/trios for which we perform direct inference from parental genomes, resulting in a dataset comprising a total...
Explore content About the journal Publish with us Sign up for alerts RSS feed nature nature communications articles article Article Open access Published: 21 November 2024 Metabolomic and genomic prediction of common diseases in 700,217 participants in three national biobanks Nightingale Health Biobank...
Abdelhafiz1, Mamoun Ahram2, Maha Emad Ibrahim3, Alya Elgamri4, Ehsan Gamel5, Rania Labib6 and Henry Silverman7* Abstract Background: Biobanks have recently been established in several low- and middle-income countries (LMICs) in the Arab region of the Middle...
Advancements in data acquisition and computational methods are generating a large amount of heterogeneous biomedical data from diagnostic domains such as clinical imaging, pathology, and next-generation sequencing (NGS), which help characterize individua
In the realm of global health, the management of chronic diseases has emerged as an increasingly prominent challenge. Chronic illnesses such as cardiovascular diseases, diabetes, and cancer pose not only a severe threat to individual health but also impose a significant burden on public health system...
(GWAS) of LDH in the FinnGen project and in Estonian and UK biobanks, followed by a genome-wide meta-analysis to combine the results. In the meta-analysis, we identify 41 loci that have not been associated with LDH in prior studies on top of the 23 known risk loci. We detect LDH-...