Biobanks生物银行知多少 随着一批国家的生物银行的完成和结果公布,多个 Biobank 的 GWAS summary statistics 文件已经公开,这里列下不同国家的相关资源,这些资源基本是使用开源的pheweb工具进行数据公开的,多数开放数据下载。 当然,对我们来说最有用的是国人的或者是东亚的。不得不承认,国外在数据开放方面走在了我们前...
By using these datasets, we have conducted genome-wide association studies (GWAS) of various human complex traits and expanded the genetic map of disease susceptibility in non-European populations. As a representative study, a phenome-wide analysis of 220 traits, including diseases, clinical ...
Conditional and joint multiple-SNP analysis of GWAS summary statistics identifies additional variants influencing complex traits. Nat. Genet. 44, 369–375 (2012). Article CAS PubMed PubMed Central Google Scholar Wu, Y., Zheng, Z., Visscher, P. M. & Yang, J. Quantifying the mapping ...
Data availability The individual-level genotype and phenotype data are available through formal application to the UKB (http://www.ukbiobank.ac.uk). GWAS summary statistics for the 2,989 binary traits from our analysis of the UKB data are fully available at http://fastgwa.info/ukbimpbin and...
So far, PRS models that use GWAS summary statistics have been favored over those that use individual-level data due to their computational efficiency and data access restrictions. These models have been comprehensively reviewed recently.10,42 We here explored the prediction performance of two widely ...
3Department of Histopathology, St James's Hospital, 4Biobank Ireland Trust, Dublin, Ireland Abstract: In response to the increasing global demand for high quality biospecimens and data for biomedical research, biobanking is rapidly gaining popularity as an efficient and user-friendly platform for tran...
Gene-based analyses were performed using MAGMA,39 derived from SNP summary data from the GWAS of alcohol consumption in this sample. The 1000 genomes European reference panel (phase 1, release 3) was used to account for LD in the sample. SNPs were mapped to genes using the NCBI 37.3 gene...
Further analyses of information from GWAS, combined with the results from molecular toxicology analyses, are crucial to facilitating our future studies. Therefore, the longitudinal MEWHC will be continued, and the standardization of the biobank management system and expansion of the specimen database ...
GWAS: Genome-wide association study; GWD: Gambian in Western Division, The Gambia—Mandinka; IBS: Iberian populations in Spain; ITU: Indian Telugu in the UK; JPT: Japanese in Tokyo, Japan; KHV: Kinh in Ho Chi Minh City, Vietnam; LD: Linkage disequilibrium; LWK: Luhya in Webuye, Kenya...
This research has been conducted using the UK Biobank Resource under application number 16549. We would like to thank the participants and researchers from UK Biobank who significantly contributed or collected data. We thank the GABRIEL consortium and the EAGLE consortium for providing GWAS summary st...