DESCRIPTION: UK Biobank is a large-scale biomedical database and research resource, containing in-depth genetic and health information from half a million UK participants. The database is regularly augmented with additional data and is globally accessible to approved researchers undertaking vital research...
Data availability The individual-level genotype and phenotype data are available through formal application to the UKB (http://www.ukbiobank.ac.uk). GWAS summary statistics for the 2,989 binary traits from our analysis of the UKB data are fully available at http://fastgwa.info/ukbimpbin and...
该研究使用单核苷酸多态性 (Single Nucleotide Polymorphism, SNP) 作为工具变量,行为因素表型的SNP数据从GWAS目录和MR-Base库获取,前列腺癌表型的基因数据则来自于PRACTICAL、GAME-ON/ELLIPSE联盟、FinnGen、ChinaPCa联盟以及BioBank Japan,基于随机效应逆方差加权法对不同行为因素与前列腺癌之间的因果关联进行评估。 研究结...
Data and code availability The all-biobank and ancestry-specific GWAS summary statistics are publicly available for downloading at https://www.globalbiobankmeta.org/resources and browsed at the PheWeb Browser http://results.globalbiobankmeta.org/. The PRS weights re-estimated using PRC-CS-auto fo...
The GWAS summary statistics for BBJ are available at the National Bioscience Database Center Human Database with the accession code hum0014. The UKB analysis was conducted via the application 31063, and its GWAS summary statistics are available at http://www.nealelab.is/uk-biobank. This study ...
For the outcomes of the MR analysis, we selected 8 of the 14 diseases from GBMI on the basis that we had full GWAS summary statistics in both European and African ancestries and relatively good statistical power (more than 100 cases). The eight disease outcomes included idiopathic pulmonary ...
3Department of Histopathology, St James's Hospital, 4Biobank Ireland Trust, Dublin, Ireland Abstract: In response to the increasing global demand for high quality biospecimens and data for biomedical research, biobanking is rapidly gaining popularity as an efficient and user-friendly platform for tran...
3Department of Histopathology, St James's Hospital, 4Biobank Ireland Trust, Dublin, Ireland Abstract: In response to the increasing global demand for high quality biospecimens and data for biomedical research, biobanking is rapidly gaining popularity as an efficient and user-friendly platform for tran...
264 UK Biobank participants of European ancestry. Results are compiled in a publicly accessible database that allows querying genome-wide association results for 9,113,133 genetic variants, as well as downloading GWAS summary statistics for over 30 million imputed genetic variants (>23 billion ...
since we observe that most factors are significantly related to these features (Methodsand Supplementary Table10). We also create polygenic scores (PGS) in the National Longitudinal Study of Adolescent to Adult Health (Add Health31) on the basis of factor GWAS summary statistics to supplement and...