Results presented here show that bile acids are physiological ligands for the farnesoid X receptor (FXR), an orphan nuclear receptor. When bound to bile acids, FXR repressed transcription of the gene encoding cholesterol 7 alpha-hydroxylase, which is the rate-limiting enzyme in bile acid synthesis...
nuclear receptor liver X receptor (LXR) αnuclear receptor farnesoid X receptor (FXRnuclear receptor role in CYP7A1 regulationenterohepatic circulation and bile acid absorption regulation in ileumbile acid pool measurementcell signaling role in CYP7A1 regulation...
Bile acids are ligands for the G protein-coupled bile acid receptor 1 (TGR5) and for the nuclear hormone receptor farnesoid X receptor (FXR) The profiles of bile acids and gut microbiota influence each other; bile acids can modulate microbiota composition, which in turn regulates the size and...
序列相似性Belongs to the nuclear hormone receptor family. NR1 subfamily.Contains 1 nuclear receptor DNA-binding domain. 细胞定位Nucleus. Anti-Bile Acid Receptor NR1H4 antibody (ab85606) 应用: ICC/IF, WB 种属: Human (预测: Mouse, Hamster, Cow) Anti-Bile Acid Receptor NR1H4 antibody [322.1...
et al. Lowering bile acid pool size with a synthetic farnesoid X receptor (FXR) agonist induces obesity and diabetes through reduced energy expenditure. J. Biol. Chem. 286, 26913–26920 (2011). CAS PubMed PubMed Central Google Scholar Burris, T. P. et al. Nuclear receptors and their ...
Bile acids (BAs) are not only digestive surfactants but also important cell signaling molecules, which stimulate several signaling pathways to regulate some important biological processes. The bile- acid-activated nuclear receptor, farnesoid X receptor (FXR), plays a pivotal role in regulating bile ac...
Modica S, Petruzzelli M, Bellafante E, Murzilli S, Salvatore L, Celli N, Di Tullio G, Palasciano G, Moustafa T, Halilbasic E, Trauner M, Moschetta A (2012) Selective activation of nuclear bile acid receptor FXR in the intestine protects mice against cholestasis. Gastroenterology 142:355...
Human Bile Salt Export Pump Promoter Is Transactivated by the Farnesoid X Receptor/Bile Acid Receptor The bile salt excretory pump (BSEP, ABCb11) is critical for ATP-dependent transport of bile acids across the hepatocyte canalicular membrane and for genera... M Ananthanarayanan,N Balasubramanian...
S. et al. Structure-based drug design targeting the cell membrane receptor GPBAR1: exploiting the bile acid scaffold towards selective agonism. Sci Rep. 5, 16605 (2015).Di Leva, F. S. et al. Structure-based drug design targeting the cell membrane receptor GPBAR1: exploiting the bile acid...
Bile acids play a crucial role in dietary lipid digestion and absorption, and also act as versatile signalling molecules through the activation of the nuclear hormone receptor farnesoid X receptor-α (FXR-α) and the recently identified G-protein-coupled receptor TGR5. Bile-acid-mediated activation...