Bile acid synthesis is associated with IBS diarrheaMichael CamilleriNews
A Clostridia-rich microbiota enhances bile acid excretion in diarrhea-predominant irritable bowel syndrome. J. Clin. Invest. 130, 438–450 (2020). Article CAS PubMed Google Scholar Bárcena, C. et al. Healthspan and lifespan extension by fecal microbiota transplantation into progeroid mice. Nat...
Bile acid diarrhoea (BAD) is a commonly missed cause of chronic diarrhoea and has been demonstrated in excess of a quarter of patients who were previously diagnosed with IBS-D1,2. Functional bowel disorders such as IBS form the largest group of patients seen in a general gastroenterology clinic...
actions in the colon. They are preferentially (95%) absorbed in the terminal ileum through enterohepatic circulation. Bile acid malabsorption or bile acid diarrhea occurs when reabsorption is impaired due to ileal disease or ileal resection and bile acidss stimulate water secretion and intestinal ...
In addition, the activation of TGR5 in enteric neurons was recently shown to increase colonic motility, which may lead to bile acid-induced diarrhea (BAD). Interestingly, TGR5 induces the secretion of glucagon-like peptide-1 (GLP-1) from L-cells to enhance insulin secretion and modulate ...
Bile Acid Malabsorption Caused by Ileal Resection Two syndromes of bile acid malabsorption caused by ileal resection—bile acid diarrhea (cholerheic diarrhea) and fatty acid diarrhea (steatorrheic diarrhea)—have been identified, characterized, and symptomatic therapy has been developed... AF Hofmann ...
There is growing attention on the disruption of the gut microbiota-bile acid axis as a culprit of liver fibrosis in CLD (Albillos et al.2020; Zhang et al.2022). Studies have demonstrated that under conditions of cholestasis, the impediment to bile drainage impairs the intestinal mucosal barrier...
23 In a few patients, the movement of the bile acid pool to the distal intestine seems to overwhelm the ileal transport system, and bile acid malabsorption occurs. This is clinically manifest as diarrhea and generally responds to administration of a bile acid sequestrant. Ileal Resection ...
Synthetic pathways of bile acids and enterohepatic bile acid circulation. LDL, low-density lipoprotein; LDLR, low-density lipoprotein receptor; NTCP, Na + -dependent taurocholic acid co-transporting polypeptide; OATP, organic anion-transporting polypeptides; BSEP, bile salt export pump; ASBT, apic...
BILE ACID–INDUCED DIARRHEA The importance ofbile acid malabsorptionas a mechanism for producing chronic secretory diarrhea in the absence of ileal resection or disease is controversial.98,153,158Bile acid malabsorption has been well described as the mechanism of diarrhea when ileal disease or resection...