actions in the colon. They are preferentially (95%) absorbed in the terminal ileum through enterohepatic circulation. Bile acid malabsorption or bile acid diarrhea occurs when reabsorption is impaired due to ileal disease or ileal resection and bile acidss stimulate water secretion and intestinal ...
are associated with bile stasis and gradually progress to fibrosis, cirrhosis, and liver failure, which requires liver transplantation. Although ursodeoxycholic acid is effective in slowing the disease progression of PBC, it has limited efficacy in PSC patients. It is challenging...
There is growing attention on the disruption of the gut microbiota-bile acid axis as a culprit of liver fibrosis in CLD (Albillos et al.2020; Zhang et al.2022). Studies have demonstrated that under conditions of cholestasis, the impediment to bile drainage impairs the intestinal mucosal barrier...
For example, a decrease in the levels of the bile acid-induced ileal hormone FGF15/19 is implicated in bile acid-induced diarrhea (BAD). Conversely, the increase in bile acid absorption with subsequent overload of bile acids could be involved in the pathophysiology of liver and metabolic ...
Additionally, bile acids impact microbiome community structure and function. In this Review, we highlight how the bile acid pool is manipulated by the gut microbiota, how it is dependent on the metabolic capacity of the bacterial community and how external factors, such as antibiotics and diet, ...
23 In a few patients, the movement of the bile acid pool to the distal intestine seems to overwhelm the ileal transport system, and bile acid malabsorption occurs. This is clinically manifest as diarrhea and generally responds to administration of a bile acid sequestrant. Ileal Resection ...
Bile acidsequestrants are positively charged polymeric resins that bindbile acidsin the intestinal lumen to decrease the aqueous concentration and the efficiency of intestinal conservation of bile acids. In patients with mildbile acidmalabsorption,bile acid sequestrantsreduce diarrhea by lowering the concen...
Bile Acid Malabsorption as a Cause of Chronic Diarrhea Diagnostic Value of 7??-Hydroxy-4-Cholesten-3One in Serum in serum may serve as a novel, simple, and sensitive method for the detection of bile acidmalabsorption in patients with chronic diarrhea ofunknown origin... GH Sauter,W Munzing,...
Bile acid diarrhoea (BAD) is a common disorder resulting from increased loss of bile acids (BAs), overlapping irritable bowel syndrome with diarrhoea (IBS-D). The gut microbiota metabolises primary BAs to secondary BAs, with differing impacts on metaboli
glycosylation in the trans-Golgi network travels through the subapical compartment to the canalicular membrane where it mediates the transport of conjugated bile acids (cholic and chenodeoxycholic acid). Another apical ABC transporter is multi-drug resistance protein 3 (MDR3) (ABCB4), a flippase of...