Bile acids are central to enterohepatic signaling pathways activated through natural receptors, farnesoid X receptor [FXR mediates synthesis of fibroblast growth factor-19 (FGF-19)], and G protein-coupled bile acid receptor 1 (GPBAR1, also known as TGR5). Although bile acid diarrhea (BAD) is ...
Bile Acid Malabsorption Caused by Ileal Resection Two syndromes of bile acid malabsorption caused by ileal resection—bile acid diarrhea (cholerheic diarrhea) and fatty acid diarrhea (steatorrheic diarrhea)—have been identified, characterized, and symptomatic therapy has been developed... AF Hofmann ...
actions in the colon. They are preferentially (95%) absorbed in the terminal ileum through enterohepatic circulation. Bile acid malabsorption or bile acid diarrhea occurs when reabsorption is impaired due to ileal disease or ileal resection and bile acidss stimulate water secretion and intestinal ...
Diarrhea: Impaired feedback inhibition of bile acid synthesis associated with bile acid diarrheaPurpose: Intensity modulated radiation therapy (IMRT) is a significant therapeutic advance in prostate cancer, allowing increased tumor dose delivery and increased sparing of normal tissues. IMRT planning uses ...
Bile Acid Malabsorption Several investigators have studied the role ofbile acid malabsorption(BAM) in microscopic colitis, because patients with BAM (eg, after ileal resection) have diarrhea, and colonic infusion of bile acids in animals causes a colitis similar to lymphocytic colitis.46Villous atroph...
9 RegisterLog in Sign up with one click: Facebook Twitter Google Share on Facebook sequestrant (redirected fromBile acid sequestrant) Medical Acronyms Wikipedia se·ques·trant (sĭ-kwĕs′trənt) n. A chemical that promotes sequestration. ...
23 In a few patients, the movement of the bile acid pool to the distal intestine seems to overwhelm the ileal transport system, and bile acid malabsorption occurs. This is clinically manifest as diarrhea and generally responds to administration of a bile acid sequestrant. Ileal Resection ...
coated with a polymer so as to allow the release thereof around the lower part of the small intestine and the cecum; and medicines (for example, antilipemics) comprising a combination of bile acid re-absorption inhibitors with the above-described preparations for preventing bile acid diarrhea.do...
Use of model organisms and in vitro techniques relevant to developmental biology and medicine are acceptable, as are translational human studies.doi:10.1203/00006450-197804001-00440Heubi, J EBalistreri, W BPartin, J CSchubert, W KMcgraw, C M...
Bile acidsequestrants are positively charged polymeric resins that bindbile acidsin the intestinal lumen to decrease the aqueous concentration and the efficiency of intestinal conservation of bile acids. In patients with mildbile acidmalabsorption,bile acid sequestrantsreduce diarrhea by lowering the concen...