Bile acid biosynthesis is the main pathway of cholesterol catabolism. Bile acids are more soluble than cholesterol so are easier to excrete. As amphipathic molecules they participate in lipid digestion and absorption in the intestine and they help to excrete free cholesterol with bile. They are ...
1) bile acid biosynthesis 胆汁酸合成 1. Increase ofbile acid biosynthesisenhances the expression and activity of D-bifunctional protein in rat liver; 大鼠胆汁酸合成加强时肝D-双功能蛋白mRNA表达及活性升高 2. Objective To determine the physiological role of D-bifunctional protein(DBP)inbile acid bios...
We set out to identify the bacterial strains and enzymes responsible for the biosynthesis of bile acids unique to centenarians. 3-Oxodeoxycholic acid (3-OxoDCA) can be generated from 3-oxo-Δ4-DCA through the action of 5β-reductase (5BR), which is encoded by thebaiCDgene in a small nu...
The 7α-hydroxylation of cholesterol has been shown to be the rate-limiting step in the neutral pathway of bile acid biosynthesis (1). The gene encoding CYP7A1 is highly regulated at the transcriptional level, and its mRNA has a very short half-life (∼1.5 h). The gene encoding CYP7A...
Bile acid biosynthesis The excess of free cholesterol is toxic to cells and needs to be excreted, primarily through conversion to more polar BAs. The introduction of a hydroxyl group in cholesterol reduces the half-life and directs the oxidized molecule to excretion [12]. BA synthesis is thus...
Peroxisomes play an important role in the biosynthesis of bile acids because a peroxisomal β-oxidation step is required for the formation of the mature C 24-bile acids from C 27-bile acid intermediates. In addition, de novo synthesized bile acids are conjugated within the peroxisome. In this ...
et al. Targeted disruption of the nuclear receptor FXR/BAR impairs bile acid and lipid homeostasis. Cell 102, 731–744 (2000). Article CAS PubMed Google Scholar Sanyal, S. et al. Involvement of corepressor complex subunit GPS2 in transcriptional pathways governing human bile acid biosynthesis....
A regulatory cascade of the nuclear receptors FXR, SHP-1, and LRH-1 represses bile acid biosynthesis Mol. Cell, 6 (2000), pp. 517-526 this issue View PDFView articleView in ScopusGoogle Scholar 7 G.D. Hammer, H.A. Ingraham Steroidogenic factor-1: its role in endocrine organ development...
Biochemical site of regulation of bile acid biosynthesis in the rat. The production of bile salts by rat liver is regulated by a feedback mechanism, but it is not known which enzyme controls endogenous bile acid synthesis. I... S Shefer,S Hauser,I Bekersky,... - 《Journal of Lipid Rese...
Molecular basis for feedback regulation of bile acid synthesis by nuclear receptors. Mol. Cell 6, 507–515 (2000). Article CAS PubMed Google Scholar Goodwin, B. et al. A regulatory cascade of the nuclear receptors FXR, SHP-1, and LRH-1 represses bile acid biosynthesis. Mol. Cell 6, ...