1) bile acid biosynthesis 胆汁酸合成 1. Increase ofbile acid biosynthesisenhances the expression and activity of D-bifunctional protein in rat liver; 大鼠胆汁酸合成加强时肝D-双功能蛋白mRNA表达及活性升高 2. Objective To determine the physiological role of D-bifunctional protein(DBP)inbile acid bios...
bile acid donzhiSU0nlei胆汁酸类(bile acid)一类从脊椎动物肝脏中分泌出来的胆烷酸衍生物。胆汁酸在动物体。切产气_皂黯篡紧i髻i翁苹黑幕,:111几针遇:娜H酞胺键连接构成甘氨或牛磺胆汁‘「Al叮rH秘H酸,并以钠盐或钾盐形式存在。、/乏、、言产 高等动物的胆汁酸基本结构为H24个碳原子的胆烷酸(图1),而...
biosynthesis of bile acids in man. hydroxylation of the c27-steroid side chain. biosynthesis of bile acids in man hydroxylation of the c27-steroid side chain CA, cholic acidCBA, conjugated bile acidsCDCA, chenodeoxycholic acidCYP27A1, sterol 27-hydroxylaseThe liver is the central organ involved ...
Peroxisomes play an important role in the biosynthesis of bile acids because a peroxisomal β-oxidation step is required for the formation of the mature C 24-bile acids from C 27-bile acid intermediates. In addition, de novo synthesized bile acids are conjugated within the peroxisome. In this ...
Insulin is also a known regulator of bile acid biosynthesis. Thus, recently it has been shown that short term treatment of human primary hepatocytes with physiological concentrations of insulin activates 7α-hydroxylase expression, whereas longer incubation suppresses it (28). Thus, to investigate ...
Unlike a block in intestinal apical bile acid uptake, genetic ablation of basolateral bile acid export disrupts the classical homeostatic control of hepatic bile acid biosynthesis. 展开▼ 机译:根尖钠依赖性胆汁酸转运蛋白(Asbt)负责转运穿过肠刷缘膜。但是,负责基底外侧胆汁酸出口进入门脉循环的载体尚待...
NIH 1989F32 GM Molecular Cloning of Bile Acid Biosynthesis GenesJelinek, Diane F. / University of Texas Sw Medical Center Dallas NIH 1988F32 GM Molecular Cloning of Bile Acid Biosynthesis GenesJelinek, Diane F. / University of Texas Sw Medical Center Dallas Comments Be the first to commen...
Biochemical site of regulation of bile acid biosynthesis in the rat. The production of bile salts by rat liver is regulated by a feedback mechanism, but it is not known which enzyme controls endogenous bile acid synthesis. I... S Shefer,S Hauser,I Bekersky,... - 《Journal of Lipid Rese...
Cholesterol 7-alpha-hydroxylase (CYP7A1) is the key enzyme that commits cholesterol to the neutral bile acid biosynthesis pathway and is highly regulated. In the current studies, we have uncovered a role for the transcriptional co-activator PGC-1alpha in CYP7A1 gene transcription. PGC-1alpha ...
Bile acid formation represents an important pathway for elimination of cholesterol, and the sterol 12α-hydroxylase is a branch-point enzyme in the bile acid biosynthetic pathway, which determines the ratio of cholic acid to chenodeoxycholic acid. Treatment of mice for 1 week with the peroxisome ...