Benjamini and Hochberg FDR (BH) 这是我们最常用的校正P-value控制假阳性率的方式。假设针对10000个基因进行了统计检验,对所有的原始P-value进行由小到大的排序分别为p1, p2, ..., p10000,校正后的FDR为:p1*10000/1, p2*10000/2, ..., p10000*10000/10000。与Bonferroni correction一致的地方是都乘以了...
We define an adaptive procedure for control of the false discovery rate that is uniformly more powerful than the procedure of Benjamini and Hochberg. The power gain is tiny, however, and only appreciable for small numbers of hypotheses. We illustrate the new method with the case of two ...
FDR控制(BH方法) 本文主要是对Yoav Benjamini 和Yosef Hochberg在1995年发表的文章Controlling the False Discovery Rate: A Practical and Powerful Approach to Multiple Testing进行简要总结。 1、为什么要进行多重假设检验 在单个假设检验中,假设m次假设检验相互独立,南无根据上表可得 P(决定正确)=1-α;P(决定错误...
FDR校正旨在控制这一问题,其中一种常用的方法就是Benjamini-Hochberg(BH)方法。本文将介绍FDR校正的基本概念,特别是BH方法,并提供Python代码示例。 ## Python 代码示例 流程图 原创 mob64ca12e8a030 5天前 9阅读 5700BH45 Motorola Canopy 45M BH点对点系统 运营商和ISP需要可靠、安全的点对点链路。通过...
The FPKM of each gene was calculated based on the length of the gene and the count of reads mapped to this gene. The resulting p-values were adjusted using Benjamini and Hochberg’s approach for controlling the false discovery rate (FDR). Differential expression analysis of mRNAs To compare ...
Benjamini, Y. & Hochberg, Y. (1995) Controlling the false discovery rate: A practical and powerful approach to multiple testing. Journal of the Royal Statistical Society, Series B (Methodological). 57(1), 289-300. Benjamini, Y. & Yekutieli, D. (2001) The control of the false discovery ...
FDR校正旨在控制这一问题,其中一种常用的方法就是Benjamini-Hochberg(BH)方法。本文将介绍FDR校正的基本概念,特别是BH方法,并提供Python代码示例。 ## Python 代码示例 流程图 原创 mob64ca12e8a030 8小时前 0阅读 通过案例学调优之--动态视图(v$bh和x$bh) 通过案例学调优之--动态视图(v$bh和x$bh)v$bh与...
How to Interpret Regression Analysis Results: P-values and Coefficients null hypothesis:coefficient is 0,如果p-value小于0.05,我们就可以拒绝零假设。 multiple testing Benjamini and Hochberg's method aggregated FDR FDR with group info Hu, James X., Hongyu Zhao, and Harrison H. Zhou. "False discover...
Benjamini–Hochberg procedure Benjamini–Hochberg–Yekutieli procedure 例如,BH: , ,所以q-value的期望即是FDR,所以,求出每个gene的q-value即可 原先每个gene都有自己的p值: 可靠gene的p值满足: 可靠gene的q值满足: 其中,k是gene number号,a是自己设定的0.05,m是所有gene个数,在这里是6; ...
Statistical analysis was performed by Mann–Whitney-U-test and p value corrected by Benjamini Hochberg. F Correlation of gene expression of the pooled BCL2 genes (BCL2, BCL2L1 and MCL-1) and the neural stem cells markers (NES, SOX2 and SOX9) based on single-cell sequencing of GBM cells...