下面我们将逐步回答Benjamini和Hochberg假阳率的计算和应用,主要包括以下几个步骤: 1.收集数据并进行单个假设检验: 在开始应用BH方法之前,首先需要收集数据并进行一系列的单个假设检验。例如,基因表达数据中的每个基因可以视为一个独立的假设检验问题,我们可以通过t检验、方差分析(ANOVA)等测试基因差异是否显著。 2.计算...
method指定矫正用的方法。可以用的方法可以通过运行“p.adjust.methods ”来查看,有: Bonferroni correction ("bonferroni") ,Holm (1979) ("holm"), Hochberg (1988) ("hochberg"), Hommel (1988) ("hommel") and Benjamini & Hochberg (1995) ("fdr"或“BH”) n为比较次数 实例: # BH方法p<-c(0.020...
计算Benjamini和Hochberg(BH)的FDR是一个多步骤的过程: 1.将所有的p值按照升序排列,并赋予其一个排名。 2.对每个p值应用以下计算公式:FDR =排名/总排名数*α/ i,其中α是事先设定的FDR水平(通常为0.05),i是当前排名的顺序。 3.对于每个排序的p值,比较其与计算得到的FDR值,如果p值小于或等于FDR,则拒绝虚无...
在R中进行任何类型的统计分析时，您通常不需要重新发明轮子。p.adjust(p, method = 'hochberg', n =...
However, procedures, including the false discovery rate (FDR) controlling Benjamini鈥揌ochberg (BH) procedure, often used in such settings, being developed originally for p-values with continuous distributions, are too conservative, and so may not be as powerful as one would hope for. Therefore,...
您通常不需要重新发明轮子。p.adjust(p, method = 'hochberg', n = length(p))
However, after installing the "Calculate Adjusted P-Values" extension in SPSS, the Benjamini-Hochberg (BH) correction only appears in the descriptive statistics option but NOT when I conduct the GLM. Do I need to create a variable of only my p-values from the GLM and the...
In this tutorial, we will show you how to apply the Benjamini-Hochberg procedure in order to calculate the False Discovery Rate (FDR) and the P-Value Adjusted.The Benjamini-Hochberg procedure, also known as the False Discovery Rate (FDR) procedure, is a statistical method used in multiple ...
Using simulations as well as theoretical observations we study false discovery rate (FDR), power and misclassification probability for the Benjamini-Hochberg (BH) procedure and its modifications, as well as for various parametric and nonparametric Bayes and Parametric Empirical Bayes procedures. Our ...
RESULTS: In consideration of the variability in test results, we find that the widely used Benjamini and Hochberg's (BH) false discovery rate (FDR) ... DL Gold,JC Miecznikowski,S Liu - 《Bioinformatics》 被引量: 37发表: 2009年 Optimal weighting for false discovery rate control How to we...