The meaning of BETA-OXIDATION is stepwise catabolism of fatty acids in which 2-carbon fragments are successively removed from the carboxyl end of the chain.
Fatty Acid Activation As shown below, the first step of fatty acid oxidation is activation. A CoA molecule is added to the fatty acid to produce acyl-CoA, converting ATP to AMP in the process. Note that in this step, the ATP is converted to AMP, not ADP. Thus, activation uses the eq...
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Carnitine acetyltransferase, on the other hand, binds to all of these membranes. The enzymes of fatty acid beta-oxidation, thiolase, crotonase, and beta-hydroxyacyl-CoA dehydrogenase bind to inner membrane, but not to liposomes. The binding shows a moderate dependence on ionic strength (2-200 ...
When an n-alkane-utilizable yeast, Candida tropicalis pK233, was cultivated on butyrate, the fatty acid of shortest chain-length for beta-oxidation, as the sole source of carbon and energy, catalase and the enzymes of the fatty acid beta-oxidation system were inducibly synthesized at high leve...
This chapter focuses on the methods to measure unique metabolites, specific enzymes, and genes in fatty acid oxidation and monitor metabolic flux through the entire pathway. It also describes the methods for the diagnosis of diseases of fatty acid oxidation. Frequently, patients are identified in wh...
Fatty acid beta-oxidation (FAO) regulates cell function. Here, we aimed to investigate the effect of FAO enhanced by leptin on the characteristics of RA-FLS and elucidate the potential metabolic mechanism. Key enzymes involved in lipid metabolism were detected with qPCR in HSF, MH7A cell line ...
The fatty acid beta-oxidation pathway is important for decidualization of endometrial stromal cells in both humans and mice. Schulte MB, Moley KH (2014) The fatty acid beta-oxidation pathway is important for decidualization of endometrial stromal cells in both humans and mice. ... MB Schulte,MY...
Fatty acid beta oxidation enzyme HADHA is a novel potential therapeutic target in malignant lymphomaCancer cells, including malignant lymphoma cells, alter their metabolism, termed "metabolic reprograming," on initiation of malignant transformation as well as upon accumulation of genetic abnormalities. ...
The effects of glucose starvation on the oxidation of fatty acids were studied in excised maize (Zea mays L.) root tips. After 24 hours of glucose starvation, the rate of oxidation of palmitic acid to CO(2) by the root tips was increased 2.5-fold. Different enzyme activities were tested...