In vitro experiments have clearly shown that under conditions where ferric iron and unsaturated fatty acids are present, ascorbic acid actually promotes lipid oxidation. Whether this also occurs in vivo is not known. Citrus fruits, green peppers, cauliflower, broccoli, cabbage, and strawberries are ...
beta thalassaemia (a haemoglobinopathy) was the earliest to be associated with malaria prevalence. However, the malaria protective properties of beta thalassaemic erythrocytes remain unclear. Here we studied the mechanics
During oxidative storage, aldehydes increase significantly, on the one hand due to oxidation of alcohols by a coupled oxidation mechanism involving air oxygen and wine di- and trihydroxyphenols93 and, on the other hand, due to their biosynthesis by veil-forming yeast. This is the case for aceta...
NADP+ is a coenzyme that is widely distributed in living matter, Participates in oxidation-reduction reactions. It serves as an electron carrier in a number of reactions, being alternately oxidized (NADP+) and reduced (NADPH).NADP is a substance in which nicotinic acid amide adenine dinucleotide...
To simulate free fatty acid addition, we introduced an additional mitochondrial NAD reduction pathway to model the beta oxidation pathway. Response to calcium oscillations The cytosolic calcium in Fridlyand’s beta cell model represented average cytosolic calcium levels and was solely controlled by the...
Fukushima, “Fluorescence in situ hybridization mapping of the α and β subunits (HADHA and HADHB) of human mitochondrial fatty acid β-oxidation multienzyme complex to 2p23 and their evolution,” Cytogenetics and Cell Genetics, vol. 79, no. 3-4, pp. 221–224, 1997. [41] Z. Fu, N....
Hydroxylation and oxidation of C4 on (−)-limonene produce (−)-carvone (CS 2.10) from Mentha spicata L. (family Lamiaceae Martinov), which at a dose of 200 mg/kg protected rodent against the pain inflicted by acetic acid and formalin via a non-opioid central mechanism probably involving...
PGG has been described to exert its anticancer activity by antioxidation, anti-inflammation, anti-angiogenesis, inhibiting DNA replicative synthesis, arresting cells in G1 and S phase, autophagy-mediated senescence, and inducing apoptosis22. In the present study, we found that PGG is a novel MYC...
The term “metabolized,” as used herein, refers to the sum of the processes (including, but not limited to, hydrolysis reactions and reactions catalyzed by enzymes, such as, oxidation reactions) by which a particular substance is changed by an organism. Thus, enzymes may produce specific ...
The present disclosure discloses compounds capable of modulating the activity of α-amino-β-carboxymuconic acid semialdehyde decarboxylase (ACMSD), which are useful for the prevention and/or the treatment of diseases and disorders associated with defects in NAD+ biosynthesis, e.g., metabolic disorder...