Gram-Positive Bacteriabeta-Lactamases are the commonest single cause of bacterial resistance to beta-lactam antibiotics. Numerous chromosomal and plasmid-mediated types are known and may be classified by their sequences or phenotypic properties. The ability of a beta-lactamase to cause resistance...
The most clinically relevant beta-lactamase in gram-positive organisms is the Ambler type A pencillinase produced byStaphylococcus aureus. Resistance to beta-lactams was first recognized inS. aureussoon afterpenicillin Gwas introduced into clinical practice.66Production ofpenicillinasewas the mechanism conf...
Beta-lactamase inhibitors enhance the activity ofbeta-lactamantibacterials against beta-lactamase-producing bacteria. These agents cause irreversible inhibition of many plasmid-mediated and some chromosomal beta-lactamases. They result in successful inhibition of beta-lactamases produced by gram-positive bacteri...
beta-lactamase resistant penicillin Beta-Lactamase-Positive Amoxicillin/Clavulanate-Resistant Beta-Lactamase-Producing Bacteria beta-lactamase-resistant antibiotic beta-lactamase-resistant antibiotic ▼ Complete English Grammar Rules is now available in paperback and eBook formats. ...
(d)monobactams(e.g.aztreonam)(e)beta-lactamaseinhibitors(e.g.clavulanicacid,sulbactam).A.FLEMING(1881–1955)•PenicillinG-P.notatum I.PENICILLINS (1929)Thecellwallcompletelysurroundsthecytoplasmicmembrane,maintainscellshapeandintegrity,andpreventscelllysisfromhighosmoticpressure.Thecellwalliscomposedofa...
Wallace RJ, Steele LC, Brooks DL, Luman JI, Wilson RW, McLarty JW: Amoxicillin-clavulanic acid in the treatment of lower respiratory tract infections caused by beta-lactamase-positiveHaemophilus influenzaeandBranhamella catarrhalis. Antimicrobial Agents and Chemotherapy (1985) 27:912–915 ...
beta-lactamase (redirected fromBeta lactamase) Thesaurus Medical Encyclopedia be·ta-lac·ta·mase (bā′tə-lăk′tə-mās′, -māz′, bē′-) n. Any of various enzymes that hydrolyze and inactivate beta-lactam antibiotics such as penicillin, found in many antibiotic-resistant bacteria. ...
This protein is intended to be used as a positive control for enzyme-dependent substrate hydrolysis and for use on immunoblots. Other uses include kinetic studies with novel substrates or identification of inhibitors of beta-lactamase as part of an antimicrobial program.^M^M1165 micromoles of ...
BRL 17421 was highly active against Haemophilus influenzae and Neisseria gonorrhoeae, including beta-lactamase-producing strains. The compound was markedly less active against Pseudomonas aeruginosa and Bacteroides fragilis than against the Enterobacteriaceae. Against the gram-positive bacteria, BRL 17421 ...
they do not retain activity against most strains ofS. aureussince they are easily hydrolyzed bypenicillinases(Macdougall, 2020a). Additionally, they have activity against some gram-negative cocci and non-beta-lactamase producinganaerobesbut have little activity against gram-negative rods (Beauduy & ...