beta-lactamasecarbapenemenzymeepidemiologygram-negative bacteriumAntimicrobial resistance due to the continuous selective pressure from widespread use of antimicrobials in humans, animals and agriculture has been a growing problem for last decades. KPC beta-lactamases hydrolyzed beta-lactams of all classes. ...
GRAM-negative bacteriaESCHERICHIA coliDRUG resistance in bacteriaBETA lactamasesKLEBSIELLA pneumoniaeNIGERIANSObjective: This study aims to determine the antibiotic susceptibility pattern and incidence of extended-spectrum beta-lactamase (ESBL) genes in isolates from vaginal discharge of symptomatic...
Long-Term Follow-Up after Neonatal Colonization with Extended Spectrum Beta-Lactamase Gram-Negative BacteriacarbapenemaseE.coliKlebsiella pneumoniaePediatric Research publishes original papers, invited reviews, and commentaries on the etiologies of diseases of children and disorders of development, extending ...
TEM-1 beta-lactamase is the most widespread enzyme to confer beta-lactam antibiotic resistance to gram-negative bacteria. It is a monomeric protein that requires no metals or cofactors for activity. TEM-1 beta-lactamase efficiently hydrolyzes most penicillin and cephalosporin substrates, including nit...
Background Extended-spectrum b-lactamase (ESBL) producing bacteria are growing in number worldwide and cause complications in antibiotic therapy for patients, thus raising mortality and morbidity. Aim This study aims to (a) determine the frequency rate of ESBL-producing gram-negative bacteria that ...
Beta-lactamases are found primarily in gram-negative bacteria but have also been described in S aureus. Although S aureus possessed beta-lactamase even before the discovery of penicillin, the prevalence of beta-lactamase–producing S aureus increased rapidly after its introduction into clinical use.23...
The report includes the results of in vitro and preclinical in vivo studies, which demonstrate the ability of ETX2514 to restore antimicrobial activity in combination with multiple beta-lactams against Gram-negative, multi-drug resistant pathogens. Entasis Describes Rational Design of Beta-Lactamase Inh...
It is mainly due to beta lactamase production by most of the gram negative bacilli. Beta lactamases produced by gram negative bacilli hydrolyzes most of the cephalosporins and even carbapenums. Clinicians are therefore left with very limited choice. It is seen that antibiotic selection differs with...
Bongaerts G, Roelofs-Willemse H: In vitro expression of beta-lactam-induced response by clinical gram-negative bacteria with the potential for inducible beta-lactamase production. Scand J Infect Dis 1998; 30: 579 - 583.Bongaerts G. P. A., Roelofs-Willemse H. In vitro expression of -lactam...
they do not retain activity against most strains ofS. aureussince they are easily hydrolyzed bypenicillinases(Macdougall, 2020a). Additionally, they have activity against some gram-negative cocci and non-beta-lactamase producinganaerobesbut have little activity against gram-negative rods (Beauduy & ...