During an one year period, we isolated one hundred Penicillin Resistant Gram Negative Anaerobes. Among them, 48 (46 Bacteroides and 2 Fusobacterium) had a strong Beta-Lactamase activity. Theses strains are reported in this study. The strains : every kind of samples have been included, except ...
Gram-negative bacteriaDebre Berhan Comprehensive Specialized HospitalExtended-spectrum beta-lactamase (ESBL) and carbapenemase-producing (CP) gram-negative bacteria are the major public health concerns. Gowns used by healthcare workers (HCWs) in daily practice are a source of hospital-acquired infections...
TEM-1 beta-lactamase is the most widespread enzyme to confer beta-lactam antibiotic resistance to gram-negative bacteria. It is a monomeric protein that requires no metals or cofactors for activity. TEM-1 beta-lactamase efficiently hydrolyzes most penicillin and cephalosporin substrates, including nit...
have zinc at the active site. Beta-lactamases are found primarily in gram-negative bacteria but have also been described inS aureus. AlthoughS aureuspossessed beta-lactamase even before the discovery of penicillin, the prevalence of beta-lactamase–producingS aureusincreased rapidly after its introducti...
Beta (β)-lactamases are the most important agents that confer drug resistance among gram-negative bacteria. Continuous mutations in β-lactamases make them remarkably diverse. We carried out the transcriptome analysis of 10 β-lactamase genes of Extended-Spectrum β-lactamases (ESBL), Metallo β-...
Prevalence and Predictors of Methicillin-Resistant Staphylococcus aureus (MRSA) and Extended-Spectrum Beta-Lactamase (ESBL) Gram-Negative Bacteria at Hospi... Prevalence and predictors of methicillin-resistant Staphylococcus aureus (MRSA) and extended-spectrum beta-lactamase (ESBL) Gram-negative bacteria at...
Objective: Neonatal colonization of the gut with multiresistant (ESBL= Extended spectrum betalactamase) gram-negative bacteria has become more common in recent years. The aim of this study was to investigate whether neonatal ESBL colonization becomes long-lasting or disappears.Methods: Follow-up study...
(d)monobactams(e.g.aztreonam)(e)beta-lactamaseinhibitors(e.g.clavulanicacid,sulbactam).A.FLEMING(1881–1955)•PenicillinG-P.notatum I.PENICILLINS (1929)Thecellwallcompletelysurroundsthecytoplasmicmembrane,maintainscellshapeandintegrity,andpreventscelllysisfromhighosmoticpressure.Thecellwalliscomposedofa...
Beta-Lactamase-Resistenz der neuen Cephalosporine und die antimikrobielle Wirksamkeit gegen gramnegative BazillenPublished: December 1977 Volume 5, pages 224–227, (1977) Cite this article Infection Aims and scope Submit manuscript W. E. Farrar & N. M. O'Dell 169 Accesses 3 Citations Explo...
they do not retain activity against most strains ofS. aureussince they are easily hydrolyzed bypenicillinases(Macdougall, 2020a). Additionally, they have activity against some gram-negative cocci and non-beta-lactamase producinganaerobesbut have little activity against gram-negative rods (Beauduy & ...