lactamaseSince about twenty years, following the introduction into therapeutic of the news -lactams (broad-spectrum cephalosporins, aztreonam and carbapenems), a very significant number of news -lactamases appeared. These enzymes confer to the bacteria which put them, the means of resisting these new...
(d)monobactams(e.g.aztreonam)(e)beta-lactamaseinhibitors(e.g.clavulanicacid,sulbactam).A.FLEMING(1881–1955)•PenicillinG-P.notatum I.PENICILLINS (1929)Thecellwallcompletelysurroundsthecytoplasmicmembrane,maintainscellshapeandintegrity,andpreventscelllysisfromhighosmoticpressure.Thecellwalliscomposedofa...
beta-lactamase (redirected fromBetalactamase) Thesaurus Medical Encyclopedia Related to Betalactamase:ESBL be·ta-lac·ta·mase (bā′tə-lăk′tə-mās′, -māz′, bē′-) n. Any of various enzymes that hydrolyze and inactivate beta-lactam antibiotics such as penicillin, found in many an...
beta-Lactamases and beta-Lactamase Inhibitors in the 21st Century The beta-lactams retain a central place in the antibacterial armamentarium. In Gram-negative bacteria, beta-lactamase enzymes that hydrolyze the amide bond... Tooke, Catherine L.Hinchliffe, PhilipBragginton, Eilis C.Colenso, Charlotte...
also express more than one beta-lactamase gene as well as multiple beta-lactam resistance mechanisms concurrently, including beta-lactamases, beta-lactam efflux, and loss of outer-membrane proteinporins, which are involved in the periplasmic accumulation of beta-lactam agents in gram-negative organisms...
The first metallo-beta-lactamase identified in norway is associated with a TniC-like transposon in a Pseudomonas aeruginosa isolate of sequence type 233 im... Metallo-beta-lactamases (MBLs) are an emerging problem among various clinical important Gram-negative bacilli such as Pseudomonas aeruginosa,...
A novel β-lactamase inhibitor has been isolated from Streptomyces clavuligerus ATCC 27064 and given the name clavulanic acid. Conditions for the cultivati... C.,Reading,M.,... - 《Antimicrobial Agents & Chemotherapy》 被引量: 815发表: 1977年 Crystal structure of a bacterial signal peptidase ...
beta-lactamase Enzyme (penicillin amido-beta-lactam hydrolase, EC 3.5.2.6, 377aa in E. coli) produced by some bacteria that makes them resistant to beta-lactam antibiotics. Competitively inhibited by clavulanic acid. Extended-spectrum beta lactamases (ESBLs) will degrade the ‘extended spectrum cep...
beta-lactamase Enzyme (penicillin amido-beta-lactam hydrolase, EC 3.5.2.6, 377aa in E. coli) produced by some bacteria that makes them resistant to beta-lactam antibiotics. Competitively inhibited by clavulanic acid. Extended-spectrum beta lactamases (ESBLs) will degrade the ‘extended spectrum cep...
Alarming β-lactamase-mediated resistance in multidrug-resistant Enterobacteriaceae. Curr Opin Microbiol. 13, 558–564 (2010). 5. Bouchillon, S. K., Badal, R. E., Hoban, D. J. & Hawser, S. P. Antimicrobial susceptibility of inpatient urinary tract isolates of gram- negative bacilli in ...