This study aims to clone the region of a patient positive for this SNP into a lentiviral firefly luciferase reporter vector, for use in more physiologically accurate CD34+ erythropoietic progenitor cells. If the mutations in these 尾-globin gene haplotypes, such as the mutation described in this ...
(1998) Reduced beta-globin gene expression in adult mice containing deletions of locus control region 5' HS-2 or 5' HS-3. Ann. N. Y. Acad. Sci., 850, 45-53.Ley TJ et al. Reduced beta-globin gene expression in adult mice containing deletions of locus control region 50 HS-2 or ...
Restoration of the balanced alpha/beta-globin gene expression in beta 654-thalassemia mice using combined RNAi and antisense RNA approach[J].{H}Human Molecular Genetics,2007,(21):2616-2625. Shu-Yang Xie Zhao-Rui Ren Jing-Zhi Zhang Xin-Bin Guo Qing-Xue Wang Shu Wang Dan Lin Xiu-Li Gong ...
Regulated expression of the human beta-globin gene has been demonstrated in cultured murine erythroleukemia cells and in mice after retrovirus-mediated gene transfer. However, the low titer of recombinant viruses described to date results in relatively inefficient gene transfer, which limits their useful...
The beta-globin gene cluster is located on chromosome 11. SNPs database was published by Hap Map Project. Here, novel tag SNPs on beta -globin gene cluster in Chinese Han population was reported on using Haploview 4.2. The haplotype block and LD analysis showed three blocks that were ...
Several lines of evidence have established strong links between transcriptional activity and specific post-translation modifications of histones. Here we show using RNA FISH that in erythroid cells, intergenic transcription in the human β-globin locus o
Cas9-AAV6 gene correction of beta-globin in autologous HSCs improves sickle cell disease erythropoiesis in mice Article Open access 29 January 2021 Generation of an immortalised erythroid cell line from haematopoietic stem cells of a haemoglobin E/β-thalassemia patient Article Open access 08 Octo...
The β and δ chains of hemoglobins A and Aare very similar in structure and are encoded by genes that are tightly linked, yet in the red cell β chain production is 40 fold greater than production of the δ chain, providing an excellent model for studying the control of gene expression...
Sardinian delta beta 0-thalassemia is an inherited syndrome characterized by the inactivity of the beta-globin gene and the persistent activity of the fetal gamma-globin genes, particularly the A gamma-globin gene. Previous mapping studies with restriction enzymes failed to show any abnormality in th...
2. Beta-globin gene switching and DNase I sensitivity of the endogenous beta-globin locus in mice do not require the locus control region. [J] . Bender MA, Bulger M, Close J, Molecular cell . 2000,第2期 机译:小鼠内源性β-球蛋白基因座的β-球蛋白基因转换和DNase I敏感性不需要基因座...