Functional interaction of heat shock protein 90 and Beclin 1 modulates Toll-like receptor-mediated autophagy. FASEB J 2011 ; 25:2700-10; PMID: 21543763 ; http://dx.doi.org/ 10.1096/fj.10-167676Xu C. F., Liu J., Hsu L. C., Luo Y. P., Xiang R., Chuang T. H. (2011). ...
The expression of Beclin-1 protein was changed correspondingly during the induction, which increased after 30 minutes of induction and decreased gradually after 1 hour of induction. Human bone marrow mesenchymal stem cells could be induced into neuron-like cells in vitro by epidermal growth ...
PLP2-TM colocalizes and interacts with autophagy marker protein LC3.Interestingly,PLP2-TM interacts and deubiquitinates Beclinl to upregulate Beclinl expression and promote Beclinl interaction with STING,the key regulator for antiviral IFN signaling.Together,these results suggested that the coronavirus ...
To do so, we examined the protein level and distribution of Beclin 1 (Bcl2 interacting protein) and microtubule-associated protein 1 light chain 3 (LC3) which were previously found to promote autophagy. We found a dramatic elevation in Beclin 1 levels in the penumbra of rats challenged by ...
Knockout or knockdown of the BH3-only protein Bad reduces starvation-induced autophagy, whereas Bad overexpression induces autophagy in human cells. Gain-of-function mutation of the sole BH3-only protein from Caenorhabditis elegans, EGL-1, induces autophagy, while deletion of EGL-1 compromises ...
We first show that knockdown of the Bcl-2 homology domain 3-only protein Beclin 1 reduces...doi:10.1038/onc.2012.252C GongC BauvyG TonelliW YueM MehrpourOncogeneGong C, Bauvy C, Tonelli G, Yue W, Deloménie C, Nicolas V, . Beclin 1 and autophagy are required for the tumorigenicity...
Knockout or knockdown of the BH3-only protein Bad reduces starvation-induced autophagy, whereas Bad overexpression induces autophagy in human cells. Gain-offunction mutation of the sole BH3-only protein from Caenorhabditis elegans, EGL-1, induces autophagy, while deletion of EGL-1 compromises ...
Gain-of-function mutation of the sole BH3-only protein from Caenorhabditis elegans, EGL-1, induces autophagy, while deletion of EGL-1 compromises starvation-induced autophagy. These results reveal a novel autophagy-stimulatory function of BH3-only proteins beyond their established role as apoptosis ...