Here, we have identified the essential protein VCP/p97 (VCP, valosin-containing protein) as a novel regulator of autophagosome biogenesis, where VCP regulates autophagy induction in two ways, both dependent on Beclin-1. Utilizing small-molecule inhibitors of VCP ATPase activity, we show that VCP...
Here we discuss various mechanisms by which apoptosis negatively regulates canonical or Beclin 1-dependent autophagosome biogenesis and autophagy, and define the paradigms of the role of apoptosis in the process.Shouqing LuoAutophagy: Cancer, Other Pathologies, Inflammation, Immunity, Infection, and ...
The polyglutamine domain in ataxin 3, which is expanded in spinocerebellar ataxia type 3, allows normal ataxin 3 to interact with and deubiquitinate beclin 1 and thereby to promote autophagy. Expanded polyglutamine (polyQ) tracts in different proteins ar
In the absence of Bcl-2 binding, Beclin 1 mutants induce excessive autophagy and promote cell death. Together, these findings suggest that the Beclin 1-Bcl-2 complex functions as a brake on levels of autophagy and autophagy gene-dependent cell death. Results Cellular and Viral Bcl-2 Inhibit ...
aTHERE IS A MID DISC BULGE. THERE IS NO SPINAL CANAL OR FORAMINAL STENOSIS. 有中间圆盘船腹。 没有脊椎管或FORAMINAL狭窄。[translate] aHowever, caspase-mediated cleavage of Beclin-1-dependent autophagy and enhances apoptosis 然而, caspase斡旋的分裂的Beclin 1依赖autophagy和提高apoptosis[translate]...
Prognostic significance of Beclin 1-dependent apoptotic activity in hepatocellular carcinoma. Autophagy 2009 ; 5:380 - 2; http://dx.doi.org/ 10.4161/auto.5.3.7658 ; PMID: 19145109 [Taylor & Francis Online] ,Shi, YH, Ding, ZB, Zhou, J, Qiu, SJ, Fan, J (2009) Prognostic significance ...
Thus, the mechanism for NS5ATP9-promoted autophagy is Beclin 1-dependent in the condition of starvation, and for hepatoblastoma cell growth is also Beclin 1-dependent. 展开 关键词: AUTOPHAGY BECLIN 1 NS5ATP9 PROLIFERATION STARVATION DOI: 10.1002/jcb.25111 ...
Cardioprotection by Orientin: a Novel Mechanism via Inhibiting Autophagy involving the Beclin 1 Dependent Manner APJ受体压力诱导心肌细胞肥大蛋白偶联受体摘要:Xiulan HuangStateLiya LiuNationalitiesQinqin MaAffairsLing YuanCommissionHuiye WangandVIP中国药理通讯...
Neratinib and the drug combinations caused the co-localization of mutant RAS proteins and ERBB2 with Beclin1 and cathepsin B. The drug combination activated the AMP-dependent protein kinase that was causal in enhancing HMG Co A reductase phosphorylation. Collectively, our data reinforce the concept ...
Beclin-1-dependent autophagy protects the heart during sepsis. Circulation. 2018;138:2247–62. Article CAS Google Scholar Jin S, Tian S, Chen Y, Zhang C, Xie W, Xia X, et al. USP19 modulates autophagy and antiviral immune responses by deubiquitinating Beclin-1. EMBO J. 2016;35:866–...