Beclin-1 (Becn1) is a key protein regulating autophagy, a recycling process for unwanted components. Whether HA disturbs autophagic flux in endothelial cells via Becn1 is unknown. We hypothesize that Becn1-dependent autophagic flux will improve endothelial function and inhibit the hypertension (HTN)...
Here, we have identified the essential protein VCP/p97 (VCP, valosin-containing protein) as a novel regulator of autophagosome biogenesis, where VCP regulates autophagy induction in two ways, both dependent on Beclin-1. Utilizing small-molecule inhibitors of VCP ATPase activity, we show that VCP...
The polyglutamine domain in ataxin 3, which is expanded in spinocerebellar ataxia type 3, allows normal ataxin 3 to interact with and deubiquitinate beclin 1 and thereby to promote autophagy. Expanded polyglutamine (polyQ) tracts in different proteins ar
[translate] aHowever, caspase-mediated cleavage of Beclin-1-dependent autophagy and enhances apoptosis 然而, caspase斡旋的分裂的Beclin 1依赖autophagy和提高apoptosis [translate] 英语翻译 日语翻译 韩语翻译 德语翻译 法语翻译 俄语翻译 阿拉伯语翻译 西班牙语翻译 葡萄牙语翻译 意大利语翻译 荷兰语翻译 瑞典语...
Prognostic significance of Beclin 1-dependent apoptotic activity in hepatocellular carcinoma. Autophagy 2009; 5:380-2.Shi YH, Ding ZB, Zhou J, Qiu SJ, Fan J. Prognostic significance of Beclin 1-dependent apoptotic activity in hepatocellular carcinoma. Autophagy. 2009;5:380-2....
Serum Response Factor Promotes Dopaminergic Neuron Survival via Activation of Beclin 1-Dependent Autophagy 来自 国家科技图书文献中心 喜欢 0 阅读量: 206 作者:XY Cheng,SY Li,CJ Mao,MX Wang,AJ Chen 摘要: Serum response factor (SRF), a transcription factor highly expressed in neurons, is involved ...
Cardioprotection by Orientin: a Novel Mechanism via Inhibiting Autophagy involving the Beclin 1 Dependent Manner APJ受体压力诱导心肌细胞肥大蛋白偶联受体摘要:Xiulan HuangStateLiya LiuNationalitiesQinqin MaAffairsLing YuanCommissionHuiye WangandVIP中国药理通讯...
Yao X, Li X, Zhang D et al (2017) B cell lymphoma 2 inhibitor ABT-737 induces Beclin1- and reactive oxygen species-dependent autophagy in Adriamycin-resistant human hepatocellular carci- noma cells. Tumour Biol 39:1010428317695965. https://doi. org/10.1177/1010428317695965...
Beta-asarone reduces autophagy in a dose-dependent manner. In view of the close relationship between Beclin 1 and autophagy, we found that beta-asarone interfered with Beclin 1 function. Our studies on the mechanism by which beta-asarone attenuates autophagy indicate that it is likely that ...
Beclin-1-dependent autophagy protects the heart during sepsis. Circulation. 2018;138:2247–62. Article CAS Google Scholar Jin S, Tian S, Chen Y, Zhang C, Xie W, Xia X, et al. USP19 modulates autophagy and antiviral immune responses by deubiquitinating Beclin-1. EMBO J. 2016;35:866–...