had significant positive impact on SCI by affecting BDNF-TrkB signaling pathway. This study aims to accumulate and evaluate these data and inspect whether this signaling is effective or not.Shamsnia, Hedieh SadatGI Pharmacology Interest Group (GPIG), Universal Scientific Education and Research Network...
研究表明,BDNF-TrkB自分泌环在细胞衰老过程中起到关键作用。在神经元中,BDNF-TrkB自分泌环可以抑制细胞衰老相关的基因表达,延长细胞寿命。在间充质干细胞中,BDNF-TrkB自分泌环的激活可以增强细胞增殖能力,延缓细胞衰老。此外,BDNF-TrkB自分泌环在肌肉细胞、心脏细胞等多种细胞类型中都表现出抗衰老作用。 BDNF-TrkB自...
BDNF-TrkB自分泌环通过以下几个方面来增强衰老细胞活力:(1)激活细胞内信号通路:BDNF与TrkB结合后,可以激活PI3K/Akt、ERK等信号通路,从而促进细胞存活、增殖和分化;(2)调控基因表达:BDNF-TrkB自分泌环可以上调细胞周期调控因子、抗衰老基因等表达,降低衰老相关基因表达;(3)促进细胞代谢:BDNF-TrkB自分泌环可以增强细胞...
BDNF-TrkB自分泌环通过以下几个方面来增强衰老细胞活力:(1)激活细胞内信号通路:BDNF与TrkB结合后,可以激活PI3K/Akt、ERK等信号通路,从而促进细胞存活、增殖和分化;(2)调控基因表达:BDNF-TrkB自分泌环可以上调细胞周期调控因子、抗衰老基因等表达,降低衰老相关基因表达;(3)促进细胞代谢:BDNF-TrkB自分泌环可以增强细胞...
Obejective: To investigate the impact of curcumin (Cur) regulating the brain-derived neurotrophic factor (BDNF) /tropomyosin related kinase B receptor (TrkB) signaling pathway on neuronal apoptosis in neonatal rat with bacterial meningitis (BM). Methods: 15 rats we...
In this paper, the relationship between BDNF-TrkB signaling pathway and the generation of anxiety disorders will be reviewed.Key words: brain-derived neurotrophic factor (BDNF); tyrosine kinase receptor B (TrkB); signaling pathway; anxiety disorder焦虑障碍(anxiety disorder)是以广泛持续焦虑或反复发作...
7,8-Dihydroxyflavone protects retinal ganglion cells against chronic intermittent hypoxia-induced oxidative stress damage via activation of the BDNF/TrkB signaling pathway. Fang, Luo, Yue, Han, Zhang, Zhou, Liu, Liu, Sleep Breath(2021 May 15) The impact of antipsoriatic treatment on serum pro...
bdnf/trkb信号途径与抗肿瘤治疗 莫赛军,郑乃刚,曹文波,周琦,杨胜利* Keywords: bdnf,trkb,肿瘤,耐药性,抗肿瘤治疗 Full-Text Cite this paper Add to My Lib Abstract: ?肿瘤是目前危害人类健康的主要疾病之一。治疗肿瘤的主要手段包括手术、放疗、化疗和生物治疗等,但耐药现象的产生,导致药物治疗效果不甚理想...
This study further validated the effect of the BDNF/TrKB signalling pathway on the process of endometriosis and analysed changes in the expression of these factors, together with associated changes in the degree of dysmenorrhoea, in different parts of the endometrium at different stages. Pelvic pai...
Key words: Xuefu Zhuyu Capsule; post-stroke depression; neurotransmitter; neuronal regeneration; BDNF/TrkB/p-CREB signaling pathway 卒中后抑郁(post-stroke depression,PSD)是脑 血管疾病发生后较常见的精神障碍类并发症.研究 表明有近 30%的患者会在卒中后 5 年内出现抑郁症 症状[1],严重影响患者生活质量...