GeneexpressionMouseThis study reports that in purified cultures of postnatal cerebellar granule cells, BDNF significantly accelerated GABAA receptor 伪6 subunit (GABAA伪6) mRNA expression, a marker for terminally differentiated cerebellar granule neurons, and also accelerated p21cip1 expression. p21cip1 ...
especially in the context of psychiatric disorders, where blood has been suggested to be an alternative and useful peripheral tissue to assess biomarkers of illness, BDNF gene expression studies offer the opportunity to investigate not only the levels of...
^Buchman, A. S., Yu, L., Boyle, P. A., Schneider, J. A., De Jager, P. L., & Bennett, D. A. (2016). Higher brain BDNF gene expression is associated with slower cognitive decline in older adults. Neurology, 86(8), 735-741. ^Rex, C. S., Lauterborn, J. C., Lin, C....
22. CHAO YC, XIE F, LI X, et al. Demethylation regulation of bdnf gene expression in dorsal root ganglion neurons is implicated in opioid-induced pain hypersensitivity in rats [J]. Neurochem Int, 2016,97:91-98. 23...
(14.32±4.21)ng/ml,F=7.2545,P=0.0016].ConclusionThefunctionalpolymorphismofBDNFgene(rs6265)correlatedwithpathogenesisofSADandaffectstheexpressionofBDNFinserum.【Keywords】Brain-derivedneurotrophicfactor;Alzheimer’sdisease;Functionalpolymorphism阿尔茨海默病(AD)是一种与年龄相关的神经退行性疾病,临床主要表现为进行...
(rAA V ) and explore the mechanism of its neuroprotective ef f ects in rat neurons against b eta— am yl oi d— in du ced A lzh eim er’S d isease.M e~ od s U sing m o lecu lar clon in g techn iq ue. rA A V vecto r co ntain in g h B D N F gene(AA V — ...
BDNF gene expression is reduced in the frontal cortex of dopamine transporter knockout mice. Mol Psychiatry 8: ... Fumagalli F,Racagni G,Colombo E,and Riva MA.BDNF gene expression is reduced in the frontal cortex of dopamine transporter knockout mice [ J ]. ... F Fumagalli,G Racagni,E...
传统mBDNF检测中的难题是"对mBDNF的特异性"和"检测灵敏度"。传统试剂盒与proBDNF的交叉率比较高,难以区分检测proBDNF和mBDNF。此外,小鼠血清、血浆和人唾液中的mBDNF浓度低于传统试剂盒的标准曲线下限值,因此难以获得可靠的检测结果 。 在此背景下,FUJIFILM Wako研发了可特异性且高灵敏度检测mBDNF的ELISA试剂盒 “...
（山西医科大学生理学系，细胞生理学教育部重点实验室，太原０３０００１）【摘要】 目的：探讨脑源性神经营养因子（ＢＤＮＦ）基因过表达慢病毒载体的构建和包装，检测其在大鼠海马原代神经元中的表达。方法：利用聚合酶链式反应（ＰＣＲ）技术扩增Ｂｄｎｆ基因的ｅｘｏｎｓ４和ＣＤＳ序列，将其克隆到ｐｃＤＮＡ３...
上海博尔森生物科技有限公司生产的脑源性神经营养因子(BDNF)重组蛋白,最新报价:5000元/μg,脑源性神经营养因子(BDNF)重组蛋白[PROPERTIES]Source:ProkaryoticexpressionHost:E.coliResidues:H