Histone modifications around individual BDNF gene promoters in prefrontal cortex are associated with extinction of conditioned fear. Learn Mem. 2007;14(4):268–76. Article CAS PubMed PubMed Central Google Scholar Haggarty SJ, Tsai LH. Probing the role of HDACs and mechanisms of chromatin-...
In previous research, those with at least one copy of the methionine (met) allele in the brain-derived neurotrophic factor gene (BDNF; rs6265) had greater increases in positive mood and lower perceived exertion during exercise. This study examined whether genotype for BDNF is also related to ...
Cellular diversity in the nervous system evolves from the concerted processes of cell proliferation, differentiation, migration, survival, and activity-dependent synaptic remodelling. Identification of the molecular components responsible for these processes is tied strongly to our knowledge of neurotrophic fac...
Initial studies focused on individual candidate genes such as the brain-derived neurotrophic factor gene (BDNF), a potential susceptibility gene for OCD [176,177]. Fullana et al. [178] reported only 36% of those carrying the BDNF Met allele (associated with decreased activity-dependent BDNF ...
Moreover, the specific role of each HDAC is directly related to their specific molecular substrates. To our knowledge, more than 50 non-histone proteins have been identified as substrates for HDACs [9]. On the basis of animal tissue expression and serial analysis of gene expression (SAGE) ...
Here, we will chiefly refer to cancer-associated cachexia as a representative and widespread, albeit not the most common, form of cachexia. Of note, cachexia is also associated with acute states (see below) and, in this case, may last much longer than the causative event...
The BDNF gene may influence hippocampal morphology and function (Egan 2003, Malhotra 2004). The 5-HT2A receptor gene alters memory per- formance (de Quervain 2003). The succinate-semialdehyde dehydro- genase gene has been linked to general cognitive ability (Plomin 2004). Although these studies...
Autism spectrum disorder (ASD) is a complex neurodevelopmental condition with multifactorial origins, including the potential involvement of neurotrophins and growth factors. These molecules, which are crucial for neuronal survival, synaptic plasticity, and brain development, have been implicated in ASD path...
function. The researchers also explored how lead curbs production of BDNF in the cell nucleus. One factor, they say, may be a protein called methyl CpG binding protein 2, or MeCP2, which has been linked with RETT syndrome and autism spectrum disorders and acts to "silence" BDNF gene ...
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