1. N. S. Joshi, W. Cui, A. Chandele, H. K. Lee, D. R. Urso, J. Hagman, L. Gapin, S. M. Kaech, Inflammation directs memory precursor and short-lived effector CD8+ T cell fates via the graded expression of T-bet transcription factor. Immunity 27, 281–295 (2007). 2. S...
BCL11BbiomarkermutationprognosisT-cell lymphomaBackground Molecular genetics serve a critical role in constructing risk stratification for hematological malignancies, but T-cell lymphoma (TCL) still lacks molecular genetic information for supplement risk stratification in predicting the prognosis of TCL ...
他们在《Heliyon》期刊上发表了题为 “T and NK cell functionality in a patient harboring heterozygous novel BCL11B p.Asp632fsAla*91 and STX11 p.R129P mutations” 的论文,试图揭开 BCL11B 和 STX11 杂合突变与疾病之间的神秘面纱23。 研究人员为了深入探索,运用了多种关键技术方法。首先是基因测序技术,...
9月22日,中国科学院广州生物医药与健康研究院李鹏团队和刘兴国团队共同在国际学术期刊EMBO Journal上发表了题为BCL11B and the NuRD complex cooperatively guard T-cell fate and inhibit OPA1-mediated mitochondrial fusion in T cells的研究成...
英文名称:B-cell lymphoma/leukemia 11B (BCL11B) 结构与功能 结构:BCL11B基因编码一个C2H2型锌指蛋白,该蛋白具有与BCL11A相似的结构特征。 功能: T细胞发育与分化:BCL11B在T细胞发育的各个阶段都有表达,并调控T细胞的增殖和分化。它是T细胞身份维持的重要因子,对T细胞的发育过程起关键作用。
Laboratory analysis revealed eosinophilia and elevated T helper central memory cell count. He also had multiple food allergies and chronic eczema since infancy. Dental anomalies, refractive error, feeding difficulties, hirsutism or seizures were absent. Brain magnetic resonance imaging (MRI) was normal....
We developed a targeted delivery system for BCL11B siRNA (siBCL11B) using generation 5 polyamidoamine (G5-PAMAM) dendrimers conjugated with the sgc8 aptamer, which specifically binds to the T-ALL cell membrane protein PTK7. This nanoparticle, designated G5-sgc8-siBCL11B, was designed to selec...
CategoryTranscription Factors; T Cell Receptor Signaling BackgroundCtip2是哺乳动物胸腺细胞发育过程中 T 淋巴细胞分化和存活的关键调节因子。通过调节受体蛋白 CCR7 和 CCR9 的表达来控制造血干细胞对趋化信号的反应性。 包装清单: 产品编号产品名称包装
目的探究GATA3和bcl-11b在外周T细胞淋巴瘤(peripheral T-cell lymphoma,PTCL)中的表达情况及其与临床病理特征之间的关系。 方法利用Oncomine数据库和GEO数据库分析GATA3和bcl-11b mRNA在PTCL中的表达水平;收集山西省肿瘤医院2010年1月至2020年6月间诊断为PTCL的127例患者病例资料及石蜡标本,制作组织芯片,采用免疫组织化...
The transcription factor Bcl11b is expressed in all T cell subsets and progenitors, starting from the DN2 stage of T cell development, and it regulates critical processes implicated in the development, function, and survival of many of these cells. Among the common roles of Bcl11b in T cell...